Imperial College London
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ProfessorJulianJones

Faculty of Engineering, Department of Materials

Professor of Biomaterials
 
 
 
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Contact

 

+44 (0)20 7594 6749julian.r.jones

 
 
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Location

 

207GoldsmithSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nelson:2021:10.1016/j.msec.2021.111964,
author = {Nelson, M and Li, S and Page, SJ and Shi, X and Lee, PD and Stevens, MM and Hanna, JV and Jones, JR},
doi = {10.1016/j.msec.2021.111964},
journal = {Materials Science and Engineering: C},
pages = {1--12},
title = {3D printed silica-gelatin hybrid scaffolds of specific channel sizes promote collagen Type II, Sox9 and Aggrecan production from chondrocytes},
url = {http://dx.doi.org/10.1016/j.msec.2021.111964},
volume = {123},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Inorganic/organic hybrids have co-networks of inorganic and organic components, with the aim of obtaining synergy of the properties of those components. Here, a silica-gelatin sol-gel hybrid “ink” was directly 3D printed to produce 3D grid-like scaffolds, using a coupling agent, 3-glycidyloxypropyl)trimethoxysilane (GPTMS), to form covalent bonds between the silicate and gelatin co-networks. Scaffolds were printed with 1 mm strut separation, but the drying method affected the final architecture and properties. Freeze drying produced <40 μm struts and large ~700 μm channels. Critical point drying enabled strut consolidation, with ~160 μm struts and ~200 μm channels, which improved mechanical properties. This architecture was critical to cellular response: when chondrocytes were seeded on the scaffolds with 200 μm wide pore channels in vitro, collagen Type II matrix was preferentially produced (negligible amount of Type I or X were observed), indicative of hyaline-like cartilaginous matrix formation, but when pore channels were 700 μm wide, Type I collagen was prevalent. This was supported by Sox9 and Aggrecan expression. The scaffolds have potential for regeneration of articular cartilage regeneration, particularly in sports medicine cases.
AU  - Nelson,M
AU  - Li,S
AU  - Page,SJ
AU  - Shi,X
AU  - Lee,PD
AU  - Stevens,MM
AU  - Hanna,JV
AU  - Jones,JR
DO  - 10.1016/j.msec.2021.111964
EP  - 12
PY  - 2021///
SN  - 0928-4931
SP  - 1
TI  - 3D printed silica-gelatin hybrid scaffolds of specific channel sizes promote collagen Type II, Sox9 and Aggrecan production from chondrocytes
T2  - Materials Science and Engineering: C
UR  - http://dx.doi.org/10.1016/j.msec.2021.111964
UR  - https://www.sciencedirect.com/science/article/pii/S092849312100103X?via%3Dihub
UR  - http://hdl.handle.net/10044/1/87536
VL  - 123
ER  -
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