Imperial College London
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ProfessorJulianJones

Faculty of Engineering, Department of Materials

Professor of Biomaterials
 
 
 
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Contact

 

+44 (0)20 7594 6749julian.r.jones

 
 
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Location

 

207GoldsmithSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ju:2021:10.1016/j.msec.2021.112561,
author = {Ju, Q and Zenji, T and Maçon, ALB and Norris, E and Poologasundarampillai, G and Obata, A and Jones, JR and Kasuga, T},
doi = {10.1016/j.msec.2021.112561},
journal = {Materials Science and Engineering: C},
pages = {112561--112561},
title = {Silver-doped calcium silicate sol-gel glasses with a cotton-wool-like structure for wound healing},
url = {http://dx.doi.org/10.1016/j.msec.2021.112561},
volume = {134},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Skin has excellent capacity to regenerate, however, in the event of a large injury or burn skin grafts are required to aid wound healing. The regenerative capacity further declines with increasing age and can be further exacerbated with bacterial infection leading to a chronic wound. Engineered skin substitutes can be used to provide a temporary template for the damaged tissue, to prevent/combat bacterial infection and promote healing. In this study, the sol-gel process and electrospinning were combined to fabricate 3D cotton-wool-like sol-gel bioactive glass fibers that mimic the fibrous architecture of skin extracellular matrix (ECM) and deliver metal ions for antibacterial (silver) and therapeutic (calcium and silica species) actions for successful healing of wounds. This study investigated the effects of synthesis and process parameters, in particular sintering temperature on the fiber morphology, the incorporation and distribution of silver and the degradation rate of fibers. Silver nitrate was found to decompose into silver nanoparticles within the glass fibers upon calcination. Furthermore, with increasing calcination temperature the nanoparticles increased in size from 3 nm at 600 °C to ~25 nm at 800 °C. The antibacterial ability of the Ag-doped glass fibers decreased as a function of the glass calcination temperature. The degradation products from the Ag-doped 3D non-woven sol-gel glass fibers were also found to promote fibroblast proliferation thus demonstrating their potential for use in skin regeneration.
AU  - Ju,Q
AU  - Zenji,T
AU  - Maçon,ALB
AU  - Norris,E
AU  - Poologasundarampillai,G
AU  - Obata,A
AU  - Jones,JR
AU  - Kasuga,T
DO  - 10.1016/j.msec.2021.112561
EP  - 112561
PY  - 2021///
SN  - 0928-4931
SP  - 112561
TI  - Silver-doped calcium silicate sol-gel glasses with a cotton-wool-like structure for wound healing
T2  - Materials Science and Engineering: C
UR  - http://dx.doi.org/10.1016/j.msec.2021.112561
UR  - https://www.sciencedirect.com/science/article/abs/pii/S0928493121007013
UR  - http://hdl.handle.net/10044/1/93945
VL  - 134
ER  -
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