Imperial College London
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ProfessorJulianJones

Faculty of Engineering, Department of Materials

Professor of Biomaterials
 
 
 
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Contact

 

+44 (0)20 7594 6749julian.r.jones

 
 
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Location

 

207GoldsmithSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Solanki:2023:10.3389/fbioe.2023.1125060,
author = {Solanki, A and Autefage, H and Rodriguez, A and Agarwal, S and Penide, J and Mahat, M and Whittaker, T and Nommeots-Nomm, A and Littmann, E and Payne, D and Metcalfe, A and Quintero, F and Pou, J and Stevens, M and Jones, J},
doi = {10.3389/fbioe.2023.1125060},
journal = {Frontiers in Bioengineering and Biotechnology},
pages = {1--15},
title = {Cobalt containing glass fibres and their synergistic effect on the HIF-1 pathway for wound healing applications},
url = {http://dx.doi.org/10.3389/fbioe.2023.1125060},
volume = {11},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction and Methods: Chronic wounds are a major healthcare problem, but their healing may be improved by developing biomaterials which can stimulate angiogenesis, e.g. by activating the Hypoxia Inducible Factor (HIF) pathway. Here, novel glass fibres were produced by laser spinning. The hypothesis was that silicate glass fibres that deliver cobalt ions will activate the HIF pathway and promote the expression of angiogenic genes. The glass composition was designed to biodegrade and release ions, but not form a hydroxyapatite layer in body fluid.Results and Discussion: Dissolution studies demonstrated that hydroxyapatite did not form. When keratinocyte cells were exposed to conditioned media from the cobalt-containing glass fibres, significantly higher amounts of HIF-1α and Vascular Endothelial Growth Factor (VEGF) were measured compared to when the cells were exposed to media with equivalent amounts of cobalt chloride. This was attributed to a synergistic effect of the combination of cobalt and other therapeutic ions released from the glass. The effect was also much greater than the sum of HIF-1α and VEGF expression when the cells were cultured with cobalt ions and with dissolution products from the Co-free glass, and was proven to not be due to a rise in pH. The ability of the glass fibres to activate the HIF-1 pathway and promote VEGF expression shows the potential for their use in chronic wound dressings.
AU  - Solanki,A
AU  - Autefage,H
AU  - Rodriguez,A
AU  - Agarwal,S
AU  - Penide,J
AU  - Mahat,M
AU  - Whittaker,T
AU  - Nommeots-Nomm,A
AU  - Littmann,E
AU  - Payne,D
AU  - Metcalfe,A
AU  - Quintero,F
AU  - Pou,J
AU  - Stevens,M
AU  - Jones,J
DO  - 10.3389/fbioe.2023.1125060
EP  - 15
PY  - 2023///
SN  - 2296-4185
SP  - 1
TI  - Cobalt containing glass fibres and their synergistic effect on the HIF-1 pathway for wound healing applications
T2  - Frontiers in Bioengineering and Biotechnology
UR  - http://dx.doi.org/10.3389/fbioe.2023.1125060
UR  - https://www.frontiersin.org/articles/10.3389/fbioe.2023.1125060/full
UR  - http://hdl.handle.net/10044/1/102999
VL  - 11
ER  -
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