Publications
309 results found
Walters JRF, Matthews P, 2003, Malabsorption after obesity., Case of the month
Walters JRF, 2003, Investigation of gastrointestinal function., Oxford Textbook of Medicine, Editors: Warrell, Cox, Firth, Benz, Oxford, Publisher: Oxford University Press, Pages: 503-507, ISBN: 9780192629227
Walters JRF, 2003, Differential diagnosis and investigation of malabsorption., Oxford Textbook of Medicine, Editors: Warrell, Cox, Firth, Benz, Oxford, Publisher: Oxford University Press, Pages: 577-580, ISBN: 9780192629227
Howard A, Goodlad RA, Ford D, et al., 2002, Glucagon-like peptide 2 (GLP-2) abrogates the effect of total parenteral nutrition (TPN) on intestinal amino acid and peptide transporters in rats, Conference of the Physiological-Society, Publisher: CAMBRIDGE UNIV PRESS, Pages: 54P-54P, ISSN: 0022-3751
Barley NF, Hayat JO, Bhattacharjee A, et al., 2002, Expression of the human intestinal epithelial calcium transporter ECaC2/CaT1, GUT, Vol: 50, Pages: A94-A94, ISSN: 0017-5749
Popat S, Hearle N, Bevan S, et al., 2002, A genetic analysis of coeliac disease, GUT, Vol: 50, Pages: A92-A92, ISSN: 0017-5749
Walters JR, Barley NF, Hayat JO, et al., 2002, Studies of the expression of the human intestinal epithelial calcium transporter ECaC2/CaT1, Publisher: W B SAUNDERS CO, Pages: A520-A520, ISSN: 0016-5085
Popat S, Hearle N, Hogberg L, et al., 2002, Variation in the <i>CTLA4/CD28</i> gene region confers an increased risk of coeliac disease, ANNALS OF HUMAN GENETICS, Vol: 66, Pages: 125-137, ISSN: 0003-4800
- Author Web Link
- Cite
- Citations: 36
Walters JR, 2002, New advances in the molecular and cellular biology of the small intestine, Curr Opin Gastroenterol, Vol: 18, Pages: 161-167, ISSN: 0267-1379
Tait NP, Nolan DJ, Nolan DJ, et al., 2002, The gastrointestinal tract, Textbook of Diagnostic Imaging in the Elderly, Pages: 133-168, ISBN: 9781899066889
Barley NF, O'Callaghan D, Howard A, et al., 2001, The epithelial calcium channel ECAC2 is the apical membrane calcium transporter expressed in human intestine., Publisher: W B SAUNDERS CO, Pages: A18-A18, ISSN: 0016-5085
Howard A, Rugg-Gunn P, Goodlad RL, et al., 2001, Regional differences in small intestinal nutrient transporter transcript expression during total parenteral nutrition., Publisher: FEDERATION AMER SOC EXP BIOL, Pages: A824-A824, ISSN: 0892-6638
- Author Web Link
- Cite
- Citations: 1
Kitchen P, FitzGerald A, Mandir N, et al., 2001, The effect of glucagon-like peptide-2, epidermal growth factor and glutamine on intestinal growth, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: A19-A19, ISSN: 0017-5749
Barley NF, O'Callaghan D, Howard A, et al., 2001, A novel epithelial calcium channel and human intestinal calcium absorption, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: A81-A81, ISSN: 0017-5749
Kitchen PA, Walters JRF, 2001, Molecular and cellular biology of small-bowel mucosa, CURRENT OPINION IN GASTROENTEROLOGY, Vol: 17, Pages: 104-109, ISSN: 0267-1379
- Author Web Link
- Cite
- Citations: 3
Barley NF, Howard A, O'Callaghan D, et al., 2001, Epithelial calcium transporter expression in human duodenum, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Vol: 280, Pages: G285-G290, ISSN: 0193-1857
- Author Web Link
- Cite
- Citations: 77
Sivagnanasundaram S, Islam I, Talbot I, et al., 2001, The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis, British Journal of Cancer, Vol: 84, Pages: 218-225, ISSN: 1532-1827
Accumulation of mutations in tumour suppressor genes and oncogenes has been proposed to underlie the initiation and progression of sporadic colorectal cancer (CRC). Evidence is accumulating to suggest that the caudal homeobox gene CDX2 is implicated in the pathogenesis of CRC. The CDX2 transcription factor is expressed in intestinal epithelium and is markedly down-regulated in colon tumours. Furthermore, Cdx2 heterozygous null mice develop multiple intestinal tumours. In this present study, we have investigated CDX2 as a potential candidate gene for sporadic CRC by a thorough search of all exons and exon/intron boundaries for DNA polymorphisms and rare variants in a panel of CRC tumours. 6 polymorphisms were identified and the haplotypes determined. In addition two rare variants were found, one of which was only identified in DNA from a CRC case. Loss of heterozygosity was observed in 3 out of 28 informative CRC cases. A possible association between particular haplotypes and tumour progression was also suggested by the data. In addition a preliminary analysis of the relative expression of CDX2 alleles in tumour/normal tissue suggested some variation in the levels, however further analysis is required before any conclusions can be drawn. While CDX2 mutations predisposing to sporadic CRC have not been identified, this study has established that loss of CDX2 contributes towards the progression of some sporadic CRC tumours.
Sivagnanasundaram S, Islam I, Talbot I, et al., 2000, The homeobox gene <i>CDX2</i> in colorectal carcinomas;: a genetic analysis., Publisher: CELL PRESS, Pages: 89-89, ISSN: 0002-9297
Shaw-Smith CJ, Coffey AJ, Huckle E, et al., 2000, Improved method for detecting differentially expressed genes using cDNA indexing, BIOTECHNIQUES, Vol: 28, Pages: 958-+, ISSN: 0736-6205
- Author Web Link
- Cite
- Citations: 4
Kitchen PA, Barley N, FitzGerald AF, et al., 2000, The trophic effects on the small intestine of glucagon-like peptide 2 and epidermal growth factor are additive, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: A33-A33, ISSN: 0017-5749
Barley NF, Shaw-Smith CJ, Legon S, et al., 2000, The human ileal bile acid binding protein promoter transduces increases in gene expression by the transcription factor CDX2 and bile salts., Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: A47-A47, ISSN: 0017-5749
Kitchen PA, FitzGerald AF, Mandir N, et al., 2000, Glucagon-like peptide 2 and epidermal growth factor, but not glutamine, have additive effects on intestinal growth., GASTROENTEROLOGY, Vol: 118, Pages: A1104-A1104, ISSN: 0016-5085
Kitchen PA, FitzGerald AJ, Barley N, et al., 2000, Glucagon-like peptide 2 stimulates proliferation, differentiation and gene expression in the small intestine of TPN rats, GUT, Vol: 46, Pages: A65-A65, ISSN: 0017-5749
Kitchen PA, Barley N, Mandir N, et al., 2000, The effects of glutamine and glucagon-like peptide 2 on the intestine., Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: A65-A65, ISSN: 0017-5749
Barley NF, Legon S, Walters JR, 2000, Effects of homeobox transcription factors CDX2 and PDX1 on the calbindin-D9K promoter., Publisher: W B SAUNDERS CO, Pages: A287-A287, ISSN: 0016-5085
Barley NF, Shaw-Smith CJ, Legon S, et al., 2000, Interactions of the transcription factor CDX2 and bile salts with the human ileal bile acid binding protein gene., Publisher: W B SAUNDERS CO, Pages: A589-A589, ISSN: 0016-5085
Howard A, Jordinson M, Goodlad RA, et al., 2000, Changes in expression of intestinal peptide and amino acid transporters in rats fed by total parenteral nutrition., GASTROENTEROLOGY, Vol: 118, Pages: A72-A73, ISSN: 0016-5085
Kitchen PA, Barley NF, FitzGerald AF, et al., 2000, Effect of glucagon-like peptide 2 on functional and transcription factor gene expression in the small intestine., GASTROENTEROLOGY, Vol: 118, Pages: A559-A559, ISSN: 0016-5085
Barley NF, Howard A, Legon S, et al., 2000, Identification and expression of the human intestinal epithelial apical membrane calcium transporter., GASTROENTEROLOGY, Vol: 118, Pages: A70-A70, ISSN: 0016-5085
Walters JRF, 2000, Bile acids are physiological ligands for a nuclear receptor, GUT, Vol: 46, Pages: 308-309, ISSN: 0017-5749
- Author Web Link
- Cite
- Citations: 19
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.