Publications
309 results found
Wallis K, Walters JRF, Gabe S, 2009, Short bowel syndrome: the role of GLP-2 on improving outcome, CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, Vol: 12, Pages: 526-532, ISSN: 1363-1950
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- Citations: 32
Trynka G, Zhernakova A, Romanos J, et al., 2009, Coeliac disease-associated risk variants in <i>TNFAIP3</i> and <i>REL</i> implicate altered NF-κB signalling, GUT, Vol: 58, Pages: 1078-1083, ISSN: 0017-5749
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- Citations: 146
Anderson CMH, Howard A, Walters JRF, et al., 2009, Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl−-dependent TauT (SLC6A6), Journal of Physiology, Vol: 587, Pages: 731-744, ISSN: 0022-3751
Taurine is an essential amino acid in some mammals and is conditionally essential in humans. Taurine is an abundant component of meat and fish-based foods and has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension. The purpose of this investigation was to identity the relative contributions of the solute transporters involved in taurine uptake across the luminal membrane of human enterocytes. Distinct transport characteristics were revealed following expression of the candidate solute transporters in Xenopus laevis oocytes: PAT1 (SLC36A1) is a H+-coupled, pH-dependent, Na+- and Cl−-independent, low-affinity, high-capacity transporter for taurine and β-alanine; TauT (SLC6A6) is a Na+- and Cl−-dependent, high-affinity, low-capacity transporter of taurine and β-alanine; ATB0,+ (SLC6A14) is a Na+- and Cl−-dependent, high-affinity, low-capacity transporter which accepts β-alanine but not taurine. Taurine uptake across the brush-border membrane of human intestinal Caco-2 cell monolayers showed characteristics of both PAT1- and TauT-mediated transport. Under physiological conditions, Cl−-dependent TauT-mediated uptake predominates at low taurine concentrations, whereas at higher concentrations typical of diet, Cl−-independent PAT1-mediated uptake is the major absorptive mechanism. Real-time PCR analysis of human duodenal and ileal biopsy samples demonstrates that PAT1, TauT and ATB0,+ mRNA are expressed in each tissue but to varying degrees. In conclusion, this study is the first to demonstrate both taurine uptake via PAT1 and functional coexpression of PAT1 and TauT at the apical membrane of the human intestinal epithelium. PAT1 may be responsible for bulk taurine uptake during a meal whereas TauT may be important for taurine supply to the intestinal epithelium and for taurine capture between meals.
Iacucci M, Milestone AN, Walters JR, et al., 2009, IBD Patients Maintained On Azathioprine Have Similar Bone Mineral Density to Patients Maintained On Infliximab with a Low Overall Prevalence of Osteoporosis, Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A192-A192, ISSN: 0016-5085
Pattni S, Wallis K, Dew T, et al., 2009, Reduced Fibroblast Growth Factor 19 in Patients with Short Bowel Syndrome, Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A322-A322, ISSN: 0016-5085
Wedlake L, A'Hern R, Russell D, et al., 2009, IDIOPATHIC BILE ACID MALABSORPTION IS AN IMPORTANT CAUSE OF SYMPTOMS FREQUENTLY MISDIAGNOSED AS DIARRHOEA-PREDOMINANT IRRITABLE BOWEL SYNDROME, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A6-A7, ISSN: 0017-5749
Russo EA, Harris AW, Campbell S, et al., 2009, Experience of maintenance infliximab therapy for refractory ulcerative colitis from six centres in England, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 29, Pages: 308-314, ISSN: 0269-2813
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- Citations: 33
Wedlake L, Walters JRF, Andreyev HJN, 2009, Applicability of the reported prevalence of bile salt malabsorption in irritable bowel, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 31, Pages: 161-162, ISSN: 0269-2813
Walters JRF, Bamford KB, Ghosh S, 2008, Coeliac disease and the risk of infections, GUT, Vol: 57, Pages: 1034-1035, ISSN: 0017-5749
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- Citations: 17
Balesaria S, Pell RJ, Abbott LJ, et al., 2008, Exploring possible mechanisms for primary bile acid malabsorption: evidence for different regulation of Ileal bile acid transporter transcripts In chronic diarrhoea, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, Vol: 20, Pages: 413-422, ISSN: 0954-691X
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- Citations: 31
Tasleem AM, Dew T, Balesaria S, et al., 2008, Reduced serum fibroblast growth factor 19 (FGF19) in patients with idiopathic bile acid malabsorption, Digestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A405-A406, ISSN: 0016-5085
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- Citations: 3
Wallis K, Parker HE, Le Roux CW, et al., 2008, Bile acids stimulate glucagon like peptide-2 secretion from L-cells; Possible mediation through membrane receptor TGR5, GASTROENTEROLOGY, Vol: 134, Pages: A573-A573, ISSN: 0016-5085
Russo E, Harris A, Campbell S, et al., 2008, Experience of maintenance infliximab therapy for refractory ulcerative colitis in England, GASTROENTEROLOGY, Vol: 134, Pages: A657-A657, ISSN: 0016-5085
Hunt KA, Zhernakova A, Turner G, et al., 2008, Newly identified genetic risk variants for celiac disease related to the immune response, NATURE GENETICS, Vol: 40, Pages: 395-402, ISSN: 1061-4036
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- Citations: 486
Patel VK, Pedro VL, Screaton G, et al., 2008, Peripheral blood from Crohn's disease patients demonstrate both IL-17 expressing CD4+ lymphocytes and IL-17 and interferon-gamma double expressing CD4+ lymphocytes, GASTROENTEROLOGY, Vol: 134, Pages: A508-A508, ISSN: 0016-5085
Akbar A, Yiangou Y, Facer P, et al., 2008, Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain, Gut, Vol: 57, Pages: 923-929, ISSN: 0017-5749
Objective: The capsaicin receptor TRPV1 (transient receptor potential vanilloid type-1) may play an important role in visceral pain and hypersensitivity states. In irritable bowel syndrome (IBS), abdominal pain is a common and distressing symptom where the pathophysiology is still not clearly defined. TRPV1-immunoreactive nerve fibres were investigated in colonic biopsies from patients with IBS, and this was related to abdominal pain.Methods: Rectosigmoid biopsies were collected from 23 IBS patients fulfilling Rome II criteria, and from 22 controls. Abdominal pain scores were recorded using a validated questionnaire. TRPV1-, substance P- and neuronal marker protein gene product (PGP) 9.5-expressing nerve fibres, mast cells (c-kit) and lymphocytes (CD3 and CD4) were quantified, following immunohistochemistry with specific antibodies. The biopsy findings were related to the abdominal pain scores.Results: A significant 3.5-fold increase in median numbers of TRPV1-immunoreactive fibres was found in biopsies from IBS patients compared with controls (p<0.0001). Substance P-immunoreactive fibres (p = 0.01), total nerve fibres (PGP9.5) (p = 0.002), mast cells (c-kit) (p = 0.02) and lymphocytes (CD3) (p = 0.03) were also significantly increased in the IBS group. In multivariate regression analysis, only TRPV1-immuno-reactive fibres (p = 0.005) and mast cells (p = 0.008) were significantly related to the abdominal pain score.Conclusions: Increased TRPV1 nerve fibres are observed in IBS, together with a low-grade inflammatory response. The increased TRPV1 nerve fibres may contribute to visceral hypersensitivity and pain in IBS, and provide a novel therapeutic target.
Tasleem AM, Brydon GW, Dew T, et al., 2008, Fibroblast growth factor 19 may have a role in the pathogenesis of idiopathic bile acid malabsorption, Annual General Meeting of the British-Society-of-Gastroenterology (BSG), Publisher: BMJ PUBLISHING GROUP, Pages: A20-A21, ISSN: 0017-5749
Walters JRF, 2007, Coeliac disease often goes undiagnosed., Practitioner, Vol: 251, Pages: 43-passim, ISSN: 0032-6518
van Heel DA, Franke L, Hunt KA, et al., 2007, A genome-wide association study for celiac disease identifies risk variants in the region harboring <i>IL2</i> and <i>IL21</i>, NATURE GENETICS, Vol: 39, Pages: 827-829, ISSN: 1061-4036
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- Citations: 502
Wallis K, Le Roux CW, Aylwin SJ, et al., 2007, Exaggerated postprandial GLP-2 response after Roux-en-Y gastric bypass might be causative for post surgical intestinal adaptation, Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A71-A71, ISSN: 0016-5085
Walters JR, Balesana S, Taylor V, et al., 2007, Duodenal 25-hydroxyvitamin-D-1-alpha-hydroxylase may influence human calcium absorption, Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A335-A335, ISSN: 0016-5085
Walters JRF, Balesaria S, Khair U, et al., 2007, The effects of Vitamin D metabolites on expression of genes for calcium transporters in human duodenum, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol: 103, Pages: 509-512, ISSN: 0960-0760
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- Citations: 16
Wallis K, Walters JRF, Forbes A, 2007, Review article: glucagon-like peptide 2 - current applications and future directions, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 25, Pages: 365-372, ISSN: 0269-2813
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- Citations: 53
Walters JRF, 2007, Analysis of the absolute risks in coeliac disease indicates the importance of the prevention of osteoporosis, GUT, Vol: 56, Pages: 310-310, ISSN: 0017-5749
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- Citations: 3
Walters JRF, Balesaria S, Chavele K-M, et al., 2006, Calcium channel TRPV6 expression in human duodenum: Different relationships to the vitamin D system and aging in men and women, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 21, Pages: 1770-1777, ISSN: 0884-0431
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- Citations: 37
Hunt KA, Monsuur AJ, McArdle W, et al., 2006, Lack of association of MYO9B genetic variants with coeliac disease in a British cohort, GUT, Vol: 55, Pages: 969-972, ISSN: 0017-5749
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- Citations: 50
Hunt K, Monsuur AJ, Kumar PJ, et al., 2006, Association studies of Myo9b genetic variants in a British celiac disease cohort, Digestive Disease Week/107th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A71-A71, ISSN: 0016-5085
Sangha S, Balesaria S, Walters JR, 2006, Human gene transcriptional activation by vitamin D studied in small intestinal endoscopic biopsies in short term culture, Digestive Disease Week/107th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A706-A706, ISSN: 0016-5085
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- Citations: 1
Balesaria S, Sangha S, Walters JRF, 2006, Transcriptional activation of human small intestinal gene expression studied in endoscopic biopsies in short term culture, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A87-A87, ISSN: 0017-5749
Balesaria S, Chavele KM, Khair U, et al., 2006, Evidence for different regulation of ileal bile acid transporter transcripts in patients with chronic diarrhoea, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A38-A38, ISSN: 0017-5749
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