Imperial College London
Alternate

ProfessorJulianWalters

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Gastroenterology
 
 
 
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Contact

 

+44 (0)20 3313 2361julian.walters

 
 
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Location

 

Rm368, Hammersmith HouseHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hegyi:2018:10.1152/physrev.00054.2017,
author = {Hegyi, P and Maléth, J and Walters, JR and Hofmann, AF and Keely, SJ},
doi = {10.1152/physrev.00054.2017},
journal = {Physiological Reviews},
pages = {1983--2023},
title = {Guts and gall: bile acids in regulation of intestinal epithelial function in health and disease},
url = {http://dx.doi.org/10.1152/physrev.00054.2017},
volume = {98},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and fluid to and from the luminal contents. At the same time, epithelial cells are responsible for forming a physical and biochemical barrier that prevents the entry into the body of harmful agents, such as bacteria and their toxins. Dysregulation of epithelial transport and barrier function is associated with the pathogenesis of a number of conditions throughout the intestine, such as inflammatory bowel disease, chronic diarrhea, pancreatitis, reflux esophagitis, and cancer. Driven by discovery of specific receptors on intestinal epithelial cells, new insights into mechanisms that control their synthesis and enterohepatic circulation, and a growing appreciation of their roles as bioactive bacterial metabolites, bile acids are currently receiving a great deal of interest as critical regulators of epithelial function in health and disease. This review aims to summarize recent advances in this field and to highlight how bile acids are now emerging as exciting new targets for disease intervention.
AU  - Hegyi,P
AU  - Maléth,J
AU  - Walters,JR
AU  - Hofmann,AF
AU  - Keely,SJ
DO  - 10.1152/physrev.00054.2017
EP  - 2023
PY  - 2018///
SN  - 1522-1210
SP  - 1983
TI  - Guts and gall: bile acids in regulation of intestinal epithelial function in health and disease
T2  - Physiological Reviews
UR  - http://dx.doi.org/10.1152/physrev.00054.2017
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30067158
UR  - http://hdl.handle.net/10044/1/61875
VL  - 98
ER  -
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