Imperial College London
Alternate

ProfessorJulianWalters

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Gastroenterology
 
 
 
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Contact

 

+44 (0)20 3313 2361julian.walters

 
 
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Location

 

Rm368, Hammersmith HouseHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Walters:2019:10.1172/JCI133117,
author = {Walters, JR and Marchesi, JR},
doi = {10.1172/JCI133117},
journal = {Journal of Clinical Investigation},
pages = {77--79},
title = {Chronic diarrhea, bile acids, and Clostridia.},
url = {http://dx.doi.org/10.1172/JCI133117},
volume = {130},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Excessive fecal bile acid (BA) loss causes symptoms in a large proportion of people diagnosed with irritable bowel syndrome with diarrhea, a common functional bowel disorder. This BA diarrhea (BAD) results from increased hepatic synthesis of BAs, with impaired negative feedback regulation by the ileal hormone fibroblast growth factor 19 (FGF19). In this issue of the JCI, Zhao et al. investigated BA metabolism, including fecal BAs, serum BAs, and FGF19, in patients and controls. They identified associations between fecal bacterial BA metabolism and specific microbiota, especially Clostridium scindens. These findings have been tested in a mouse model using microbiota transplants and antibiotic treatment. This group of organisms has potential as a biomarker for BAD and to be a target for therapy.
AU  - Walters,JR
AU  - Marchesi,JR
DO  - 10.1172/JCI133117
EP  - 79
PY  - 2019///
SN  - 0021-9738
SP  - 77
TI  - Chronic diarrhea, bile acids, and Clostridia.
T2  - Journal of Clinical Investigation
UR  - http://dx.doi.org/10.1172/JCI133117
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31815741
UR  - https://www.jci.org/articles/view/133117
UR  - http://hdl.handle.net/10044/1/75662
VL  - 130
ER  -
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