Imperial College London
Alternate

ProfessorJulianWalters

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Gastroenterology
 
 
 
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Contact

 

+44 (0)20 3313 2361julian.walters

 
 
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Location

 

Rm368, Hammersmith HouseHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Storr:2021:10.1055/a-1378-9627,
author = {Storr, M and Gross, M and Madisch, A and von, Arnim U and Mönnikes, H and Walters, J and Krammer, H and Keller, J},
doi = {10.1055/a-1378-9627},
journal = {Z Gastroenterol},
title = {[Bile acid diarrhea, stepchild of chronic diarrhea - prevalence, diagnosis and treatment. Update 2021].},
url = {http://dx.doi.org/10.1055/a-1378-9627},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bile acid diarrhea is one of the most frequently undiagnosed causes of chronic diarrhea. A variety of different pathophysiologic causes can underlie chronic diarrhea. Even after exclusion of the more frequent causes, up to 5% of the population remains affected by unexplained chronic diarrhea. In up to 50% within this cohort, bile acid diarrhea is the underlying cause.The various pathophysiologies leading to bile acid diarrhea are well characterized. In this way, bile acid diarrhea can be divided into primary, secondary and tertiary subtypes. Common to all causes is the increased amount of bile acids in the colon and in the faeces and the resulting secretory-osmotic diarrhea, in more severe forms in combination with steatorrhea. The diagnosis of bile acid diarrhea follows a clear algorithm which, in addition to the search for the cause and possibly a therapeutic trial, recognizes the 75SeHCAT test as the reference method for the detection of an increased loss of bile acids. In view of the chronic nature of the symptoms and the need for permanent, lifelong therapy, the use of a one-time, reliable diagnostic test is justified, though the test is currently only available at a few centers. In addition to the treatment of identifiable underlying diseases, the current treatment includes the use of drugs that bind bile acids, with additional nutritional recommendations and vitamin substitutions.The present review article summarizes the pathophysiology and importance of bile acid diarrhea and discusses the current approach towards diagnosis and treatment.
AU  - Storr,M
AU  - Gross,M
AU  - Madisch,A
AU  - von,Arnim U
AU  - Mönnikes,H
AU  - Walters,J
AU  - Krammer,H
AU  - Keller,J
DO  - 10.1055/a-1378-9627
PY  - 2021///
TI  - [Bile acid diarrhea, stepchild of chronic diarrhea - prevalence, diagnosis and treatment. Update 2021].
T2  - Z Gastroenterol
UR  - http://dx.doi.org/10.1055/a-1378-9627
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33634438
ER  -
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