Imperial College London
Alternate

ProfessorJulianWalters

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Gastroenterology
 
 
 
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Contact

 

+44 (0)20 3313 2361julian.walters

 
 
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Location

 

Rm368, Hammersmith HouseHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Savarino:2022:10.1002/ueg2.12259,
author = {Savarino, E and Zingone, F and Barberio, B and Marasco, G and Akyuz, F and Akpinar, H and Barboi, O and Bodini, G and Bor, S and Chiarioni, G and Cristian, G and Corsetti, M and Di, Sabatino A and Dimitriu, AM and Drug, V and Dumitrascu, DL and Ford, AC and Hauser, G and Nakov, R and Patel, N and Pohl, D and Sfarti, C and Serra, J and Simrén, M and Suciu, A and Tack, J and Toruner, M and Walters, J and Cremon, C and Barbara, G},
doi = {10.1002/ueg2.12259},
journal = {United European Gastroenterology Journal},
pages = {556--584},
title = {Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility},
url = {http://dx.doi.org/10.1002/ueg2.12259},
volume = {10},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Irritable bowel syndrome with diarrhoea (IBS-D) and functional diarrhoea (FDr) are the two major functional bowel disorders characterized by diarrhoea. In spite of their high prevalence, IBS-D and FDr are associated with major uncertainties, especially regarding their optimal diagnostic work-up and management. A Delphi consensus was performed with experts from 10 European countries who conducted a literature summary and voting process on 31 statements. Quality of evidence was evaluated using the grading of recommendations, assessment, development, and evaluation criteria. Consensus (defined as >80% agreement) was reached for all the statements. The panel agreed with the potential overlapping of IBS-D and FDr. In terms of diagnosis, the consensus supports a symptom-based approach also with the exclusion of alarm symptoms, recommending the evaluation of full blood count, C-reactive protein, serology for coeliac disease, and faecal calprotectin, and consideration of diagnosing bile acid diarrhoea. Colonoscopy with random biopsies in both the right and left colon is recommended in patients older than 50 years and in presence of alarm features. Regarding treatment, a strong consensus was achieved for the use of a diet low fermentable oligo-, di-, monosaccharides and polyols, gut-directed psychological therapies, rifaximin, loperamide, and eluxadoline. A weak or conditional recommendation was achieved for antispasmodics, probiotics, tryciclic antidepressants, bile acid sequestrants, 5-hydroxytryptamine-3 antagonists (i.e. alosetron, ondansetron, or ramosetron). A multinational group of European experts summarized the current state of consensus on the definition, diagnosis, and management of IBS-D and FDr.
AU  - Savarino,E
AU  - Zingone,F
AU  - Barberio,B
AU  - Marasco,G
AU  - Akyuz,F
AU  - Akpinar,H
AU  - Barboi,O
AU  - Bodini,G
AU  - Bor,S
AU  - Chiarioni,G
AU  - Cristian,G
AU  - Corsetti,M
AU  - Di,Sabatino A
AU  - Dimitriu,AM
AU  - Drug,V
AU  - Dumitrascu,DL
AU  - Ford,AC
AU  - Hauser,G
AU  - Nakov,R
AU  - Patel,N
AU  - Pohl,D
AU  - Sfarti,C
AU  - Serra,J
AU  - Simrén,M
AU  - Suciu,A
AU  - Tack,J
AU  - Toruner,M
AU  - Walters,J
AU  - Cremon,C
AU  - Barbara,G
DO  - 10.1002/ueg2.12259
EP  - 584
PY  - 2022///
SN  - 2050-6406
SP  - 556
TI  - Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility
T2  - United European Gastroenterology Journal
UR  - http://dx.doi.org/10.1002/ueg2.12259
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35695704
UR  - http://hdl.handle.net/10044/1/97633
VL  - 10
ER  -
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