Dr. Julie McDonald graduated from the University of Guelph (Guelph, Canada) with a PhD in Molecular and Cellular Biology (2013) where her thesis research focused on developing and validating a twin-vessel single-stage chemostat model of the human distal gut (nicknamed the "Robogut" or "artificial gut").
During her previous postdoctoral position at Queen's University (Kingston, Canada) she continued using the Robogut system to investigate gut microbial community dynamics in different healthy donors used for stool transplants for Clostridium difficile infection.
At Imperial College London Dr. McDonald's research focuses on studying the role of the gut microbiota in health and disease, with the aim to develop new microbiome therapeutics. She is investigating the role of microbially-produced metabolites (valerate) and enzymes (bile salt hydrolases) in the establishment and maintenance of Clostridioides difficile infection.
Dr. McDonald is also investigating the mechanism for the intestinal decolonisation of antimicrobial resistant (AMR) bacteria using faecal microbiota transplantation (FMT). This project is supported by the Wellcome Trust Institutional Strategic Support Fund (ISSF) Springboard Fellowship.
et al., 2019, Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection, Gut, ISSN:0017-5749
et al., 2019, Faecal microbiota transplant for eradication of multidrug-resistant Enterobacteriaceae: a lesson in applying best practice? Re: 'A five-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: A Randomized Clinical Trial', Clinical Microbiology and Infection, ISSN:1198-743X
et al., 2018, Inhibiting growth of clostridioides difficile by restoring valerate, produced by the intestinal microbiota, Gastroenterology, ISSN:0016-5085
et al., Functional microbiomics: evaluation of gut microbiota-bile acid metabolism interactions in health and disease, Methods, ISSN:1046-2023
et al., 2015, Metabolomic Analysis of Human Fecal Microbiota: A Comparison of Feces-Derived Communities and Defined Mixed Communities, Journal of Proteome Research, Vol:14, ISSN:1535-3893, Pages:1472-1482
et al., 2015, Simulating distal gut mucosal and luminal communities using packed-column biofilm reactors and an in vitro chemostat model, Journal of Microbiological Methods, Vol:108, ISSN:0167-7012, Pages:36-44
et al., 2013, Evaluation of microbial community reproducibility, stability and composition in a human distal gut chemostat model, Journal of Microbiological Methods, Vol:95, ISSN:0167-7012, Pages:167-174