Imperial College London
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Dr Julie McDonald

Faculty of Natural Sciences, Department of Life Sciences

Lecturer (MRC-CMBI)
 
 
 
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Contact

 

+44 (0)20 7594 5247julie.mcdonald Website

 
 
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Location

 

1.44Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Michael:2020:10.1038/s41598-020-60991-7,
author = {Michael, DR and Jack, AA and Masetti, G and Davies, TS and Loxley, KE and Kerry-Smith, J and Plummer, JF and Marchesi, JR and Mullish, BH and McDonald, JAK and Hughes, TR and Wang, D and Garaiova, I and Paduchová, Z and Muchová, J and Good, MA and Plummer, SF},
doi = {10.1038/s41598-020-60991-7},
journal = {Scientific Reports},
title = {A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being},
url = {http://dx.doi.org/10.1038/s41598-020-60991-7},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>In an exploratory, block-randomised, parallel, double-blind, single-centre, placebo-controlled superiority study (ISRCTN12562026, funded by Cultech Ltd), 220 Bulgarian participants (30 to 65 years old) with BMI 25–34.9 kg/m<jats:sup>2</jats:sup> received Lab4P probiotic (50 billion/day) or a matched placebo for 6 months. Participants maintained their normal diet and lifestyle. Primary outcomes were changes in body weight, BMI, waist circumference (WC), waist-to-height ratio (WtHR), blood pressure and plasma lipids. Secondary outcomes were changes in plasma C-reactive protein (CRP), the diversity of the faecal microbiota, quality of life (QoL) assessments and the incidence of upper respiratory tract infection (URTI). Significant between group decreases in body weight (1.3 kg, <jats:italic>p</jats:italic> < 0.0001), BMI (0.045 kg/m<jats:sup>2</jats:sup>, <jats:italic>p</jats:italic> < 0.0001), WC (0.94 cm, <jats:italic>p</jats:italic> < 0.0001) and WtHR (0.006, <jats:italic>p</jats:italic> < 0.0001) were in favour of the probiotic. Stratification identified greater body weight reductions in overweight subjects (1.88%, <jats:italic>p</jats:italic> < 0.0001) and in females (1.62%, <jats:italic>p</jats:italic> = 0.0005). Greatest weight losses were among probiotic hypercholesterolaemic participants (−2.5%, <jats:italic>p</jats:italic> < 0.0001) alongside a significant between group reduction in small dense LDL-cholesterol (0.2 mmol/L, <jats:italic>p</jats:italic> = 0.0241). Improvements in QoL and the incidence rate ratio of URTI (0.60, <jats:italic>p</jats:italic> <&thins
AU  - Michael,DR
AU  - Jack,AA
AU  - Masetti,G
AU  - Davies,TS
AU  - Loxley,KE
AU  - Kerry-Smith,J
AU  - Plummer,JF
AU  - Marchesi,JR
AU  - Mullish,BH
AU  - McDonald,JAK
AU  - Hughes,TR
AU  - Wang,D
AU  - Garaiova,I
AU  - Paduchová,Z
AU  - Muchová,J
AU  - Good,MA
AU  - Plummer,SF
DO  - 10.1038/s41598-020-60991-7
PY  - 2020///
TI  - A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-020-60991-7
UR  - http://hdl.handle.net/10044/1/78009
VL  - 10
ER  -
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