Imperial College London
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Dr Joseph van Batenburg-Sherwood

Faculty of Engineering, Department of Bioengineering

Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7244jvbsherwood Website

 
 
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Location

 

Uren 416ASir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Li:2019:10.1073/pnas.1814889116,
author = {Li, G and Lee, C and Agrahari, V and Wang, K and Navarro, I and Sherwood, JM and Crews, K and Farsiu, S and Gonzalez, P and Lin, C-W and Mitra, AK and Ethier, CR and Stamer, WD},
doi = {10.1073/pnas.1814889116},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
pages = {1714--1722},
title = {In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model},
url = {http://dx.doi.org/10.1073/pnas.1814889116},
volume = {116},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Ocular corticosteroids are commonly used clinically. Unfortunately, their administration frequently leads to ocular hypertension, i.e., elevated intraocular pressure (IOP), which, in turn, can progress to a form of glaucoma known as steroid-induced glaucoma. The pathophysiology of this condition is poorly understood yet shares similarities with the most common form of glaucoma. Using nanotechnology, we created a mouse model of corticosteroid-induced ocular hypertension. This model functionally and morphologically resembles human ocular hypertension, having titratable, robust, and sustained IOPs caused by increased resistance to aqueous humor outflow. Using this model, we then interrogated the biomechanical properties of the trabecular meshwork (TM), including the inner wall of Schlemm’s canal (SC), tissues known to strongly influence IOP and to be altered in other forms of glaucoma. Specifically, using spectral domain optical coherence tomography, we observed that SC in corticosteroid-treated mice was more resistant to collapse at elevated IOPs, reflecting increased TM stiffness determined by inverse finite element modeling. Our noninvasive approach to monitoring TM stiffness in vivo is applicable to other forms of glaucoma and has significant potential to monitor TM function and thus positively affect the clinical care of glaucoma, the leading cause of irreversible blindness worldwide.
AU  - Li,G
AU  - Lee,C
AU  - Agrahari,V
AU  - Wang,K
AU  - Navarro,I
AU  - Sherwood,JM
AU  - Crews,K
AU  - Farsiu,S
AU  - Gonzalez,P
AU  - Lin,C-W
AU  - Mitra,AK
AU  - Ethier,CR
AU  - Stamer,WD
DO  - 10.1073/pnas.1814889116
EP  - 1722
PY  - 2019///
SN  - 0027-8424
SP  - 1714
TI  - In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model
T2  - Proceedings of the National Academy of Sciences of the United States of America
UR  - http://dx.doi.org/10.1073/pnas.1814889116
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000456944600042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.pnas.org/content/116/5/1714
UR  - http://hdl.handle.net/10044/1/72993
VL  - 116
ER  -
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