Imperial College London
Portrait Picture

Dr Joseph van Batenburg-Sherwood

Faculty of Engineering, Department of Bioengineering

Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7244jvbsherwood Website

 
 
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Location

 

Uren 416ASir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Boazak:2021:10.3389/fbioe.2021.596154,
author = {Boazak, EM and King, R and Wang, J and Chu, CM and Toporek, AM and Sherwood, JM and Overby, DR and Geisert, EE and Ethier, CR},
doi = {10.3389/fbioe.2021.596154},
journal = {Frontiers in Bioengineering and Biotechnology},
pages = {1--13},
title = {Smarce1 and Tensin 4 are putative modulators of corneoscleral stiffness},
url = {http://dx.doi.org/10.3389/fbioe.2021.596154},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The biomechanical properties of the cornea and sclera are important in the onset and progression of multiple ocular pathologies and vary substantially between individuals, yet the source of this variation remains unknown. Here we identify genes putatively regulating corneoscleral biomechanical tissue properties by conducting high-fidelity ocular compliance measurements across the BXD recombinant inbred mouse set and performing quantitative trait analysis. We find seven cis-eQTLs and non-synonymous SNPs associating with ocular compliance, and show by RT-qPCR and immunolabeling that only two of the candidate genes, Smarce1 and Tns4, showed significant expression in corneal and scleral tissues. Both have mechanistic potential to influence the development and/or regulation of tissue material properties. This work motivates further study of Smarce1 and Tns4 for their role(s) in ocular pathology involving the corneoscleral envelope as well as the development of novel mouse models of ocular pathophysiology, such as myopia and glaucoma.
AU  - Boazak,EM
AU  - King,R
AU  - Wang,J
AU  - Chu,CM
AU  - Toporek,AM
AU  - Sherwood,JM
AU  - Overby,DR
AU  - Geisert,EE
AU  - Ethier,CR
DO  - 10.3389/fbioe.2021.596154
EP  - 13
PY  - 2021///
SN  - 2296-4185
SP  - 1
TI  - Smarce1 and Tensin 4 are putative modulators of corneoscleral stiffness
T2  - Frontiers in Bioengineering and Biotechnology
UR  - http://dx.doi.org/10.3389/fbioe.2021.596154
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000619473000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.frontiersin.org/articles/10.3389/fbioe.2021.596154/full
UR  - http://hdl.handle.net/10044/1/87269
VL  - 9
ER  -
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