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@article{Madekurozwa:2021:10.3389/fmedt.2021.707826,
author = {Madekurozwa, M and Bonneuil, W and Frattolin, J and Watson, D and Moore, A and Stevens, M and Moore, J and Mathiszig-Lee, J and van, Batenburg-Sherwood J},
doi = {10.3389/fmedt.2021.707826},
journal = {Frontiers in Medical Technology},
pages = {1--20},
title = {A novel ventilator design for COVID-19 and resource-limited settings},
url = {http://dx.doi.org/10.3389/fmedt.2021.707826},
volume = {3},
year = {2021}
}

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TY  - JOUR
AB  - There has existed a severe ventilator deficit in much of the world for many years, due in part to the high cost and complexity of traditional ICU ventilators. This was highlighted and exacerbated by the emergence of the COVID-19 pandemic, during which the increase in ventilator production rapidly over ran the global supply chains for components. In response, we propose a new approach to ventilator design that meets the performance requirements for COVID-19 patients, while using components that minimise interference with the existing ventilator supply chains. The majority of current ventilator designs use proportional valves and flow sensors, which remainin short supply over a year into the pandemic. In the proposed design, the core components are on-off valves. Unlike proportional valves, on-off valves are widely available,but accurate control of ventilation using on-off valves is not straight forward. Our proposed solution combines four on-of 0valves, a two-litre reservoir, an oxygen sensor and two pressure sensors. Benchtop testing of a prototype was performed with a commercially available flow analyser and test lungs. We investigated the accuracy and precision of the prototype using both compressed gas supplies and a portable oxygen concentrator, and demonstrated the long-term durability over 15 days. The precision and accuracy of ventilation parameters were within the ranges specified in international guidelines in all tests.A numerical model of the system was developed and validated against experimental data. The model was used to determine usable ranges of valve flow coefficients to increase supply chain flexibility. This new design provides the performance necessary for the majority of patients that require ventilation. Applications include COVID-19 as well as pneumonia, influenza, and tuberculosis, which remain major causes of mortality in low and middleincome countries.The robustness, energy efficiency, ease of maintenance, price and availability of on-off
AU  - Madekurozwa,M
AU  - Bonneuil,W
AU  - Frattolin,J
AU  - Watson,D
AU  - Moore,A
AU  - Stevens,M
AU  - Moore,J
AU  - Mathiszig-Lee,J
AU  - van,Batenburg-Sherwood J
DO  - 10.3389/fmedt.2021.707826
EP  - 20
PY  - 2021///
SN  - 2673-3129
SP  - 1
TI  - A novel ventilator design for COVID-19 and resource-limited settings
T2  - Frontiers in Medical Technology
UR  - http://dx.doi.org/10.3389/fmedt.2021.707826
UR  - https://www.frontiersin.org/articles/10.3389/fmedt.2021.707826/full
UR  - http://hdl.handle.net/10044/1/91495
VL  - 3
ER  -

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Dr Joseph van Batenburg-Sherwood

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