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@article{McDowell:2022:10.1167/iovs.63.2.12,
author = {McDowell, CM and Kizhatil, K and Elliott, MH and Overby, DR and Van, Batenburg-Sherwood J and Millar, JC and Kuehn, MH and Zode, G and Acott, TS and Anderson, MG and Bhattacharya, SK and Bertrand, JA and Borras, T and Bovenkamp, DE and Cheng, L and Danias, J and De, Ieso ML and Du, Y and Faralli, JA and Fuchshofer, R and Ganapathy, PS and Gong, H and Herberg, S and Hernandez, H and Humphries, P and John, SWM and Kaufman, PL and Keller, KE and Kelley, MJ and Kelly, RA and Krizaj, D and Kumar, A and Leonard, BC and Lieberman, RL and Liton, P and Liu, Y and Liu, KC and Lopez, NN and Mao, W and Mavlyutov, T and McDonnell, F and McLellan, GJ and Mzyk, P and Nartey, A and Pasquale, LR and Patel, GC and Pattabiraman, PP and Peters, DM and Raghunathan, V and Rao, PV and Rayana, N and Raychaudhuri, U and Reina-Torres, E and Ren, R and Rhee, D and Chowdhury, UR and Samples, JR and Samples, EG and Sharif, N and Schuman, JS and Sheffield, VC and Stevenson, CH and Soundararajan, A and Subramanian, },
doi = {10.1167/iovs.63.2.12},
journal = {Investigative Ophthalmology and Visual Science},
title = {Consensus recommendation for mouse models of ocular hypertension to study aqueous humor outflow and its mechanisms},
url = {http://dx.doi.org/10.1167/iovs.63.2.12},
volume = {63},
year = {2022}
}

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TY  - JOUR
AB  - Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.
AU  - McDowell,CM
AU  - Kizhatil,K
AU  - Elliott,MH
AU  - Overby,DR
AU  - Van,Batenburg-Sherwood J
AU  - Millar,JC
AU  - Kuehn,MH
AU  - Zode,G
AU  - Acott,TS
AU  - Anderson,MG
AU  - Bhattacharya,SK
AU  - Bertrand,JA
AU  - Borras,T
AU  - Bovenkamp,DE
AU  - Cheng,L
AU  - Danias,J
AU  - De,Ieso ML
AU  - Du,Y
AU  - Faralli,JA
AU  - Fuchshofer,R
AU  - Ganapathy,PS
AU  - Gong,H
AU  - Herberg,S
AU  - Hernandez,H
AU  - Humphries,P
AU  - John,SWM
AU  - Kaufman,PL
AU  - Keller,KE
AU  - Kelley,MJ
AU  - Kelly,RA
AU  - Krizaj,D
AU  - Kumar,A
AU  - Leonard,BC
AU  - Lieberman,RL
AU  - Liton,P
AU  - Liu,Y
AU  - Liu,KC
AU  - Lopez,NN
AU  - Mao,W
AU  - Mavlyutov,T
AU  - McDonnell,F
AU  - McLellan,GJ
AU  - Mzyk,P
AU  - Nartey,A
AU  - Pasquale,LR
AU  - Patel,GC
AU  - Pattabiraman,PP
AU  - Peters,DM
AU  - Raghunathan,V
AU  - Rao,PV
AU  - Rayana,N
AU  - Raychaudhuri,U
AU  - Reina-Torres,E
AU  - Ren,R
AU  - Rhee,D
AU  - Chowdhury,UR
AU  - Samples,JR
AU  - Samples,EG
AU  - Sharif,N
AU  - Schuman,JS
AU  - Sheffield,VC
AU  - Stevenson,CH
AU  - Soundararajan,A
AU  - Subramanian,P
AU  - Sugali,CK
AU  - Sun,Y
AU  - Toris,CB
AU  - Torrejon,KY
AU  - Vahabikashi,A
AU  - Vranka,JA
AU  - Wang,T
AU  - Willoughby,CE
AU  - Xin,C
AU  - Yun,H
AU  - Zhang,HF
AU  - Fautsch,MP
AU  - Tamm,ER
AU  - Clark,AF
AU  - Ethier,CR
AU  - Stamer,WD
DO  - 10.1167/iovs.63.2.12
PY  - 2022///
SN  - 0146-0404
TI  - Consensus recommendation for mouse models of ocular hypertension to study aqueous humor outflow and its mechanisms
T2  - Investigative Ophthalmology and Visual Science
UR  - http://dx.doi.org/10.1167/iovs.63.2.12
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000754416900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://iovs.arvojournals.org/article.aspx?articleid=2778419
UR  - http://hdl.handle.net/10044/1/97554
VL  - 63
ER  -

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