Imperial College London
Alternate

Dr Kambiz N. Alavian, PhD, SFHEA, FLS, FRSB

Faculty of Medicine, Department of Brain Sciences

Reader in Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 7006k.alavian Website

 
 
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Assistant

 

Mrs Hadeel Abdeen +44 (0)20 7594 7014

 
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Location

 

E507Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Weinert:2019:10.1096/fj.201802754R,
author = {Weinert, M and Millet, A and Jonas, EA and Alavian, KN},
doi = {10.1096/fj.201802754R},
journal = {The FASEB Journal},
pages = {8925--8934},
title = {The mitochondrial metabolic function of DJ-1 is modulated by 14-3-3β},
url = {http://dx.doi.org/10.1096/fj.201802754R},
volume = {33},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mitochondrial metabolic plasticity is a key adaptive mechanism in response to changes in cellular metabolic demand. Changes in mitochondrial metabolic efficiency have been linked to pathophysiological conditions, including cancer, neurodegeneration, and obesity. The ubiquitously expressed DJ-1 (Parkinsonism-associated deglycase) is known as a Parkinson's disease gene and an oncogene. The pleiotropic functions of DJ-1 include reactive oxygen species scavenging, RNA binding, chaperone activity, endocytosis, and modulation of major signaling pathways involved in cell survival and metabolism. Nevertheless, how these functions are linked to the role of DJ-1 in mitochondrial plasticity is not fully understood. In this study, we describe an interaction between DJ-1 and 14-3-3β that regulates the localization of DJ-1, in a hypoxia-dependent manner, either to the cytosol or to mitochondria. This interaction acts as a modulator of mitochondrial metabolic efficiency and a switch between glycolysis and oxidative phosphorylation. Modulation of this novel molecular mechanism of mitochondrial metabolic efficiency is potentially involved in the neuroprotective function of DJ-1 as well as its role in proliferation of cancer cells.-Weinert, M., Millet, A., Jonas, E. A., Alavian, K. N. The mitochondrial metabolic function of DJ-1 is modulated by 14-3-3β.
AU  - Weinert,M
AU  - Millet,A
AU  - Jonas,EA
AU  - Alavian,KN
DO  - 10.1096/fj.201802754R
EP  - 8934
PY  - 2019///
SN  - 0892-6638
SP  - 8925
TI  - The mitochondrial metabolic function of DJ-1 is modulated by 14-3-3β
T2  - The FASEB Journal
UR  - http://dx.doi.org/10.1096/fj.201802754R
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31034784
UR  - http://hdl.handle.net/10044/1/102829
VL  - 33
ER  -
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