Imperial College London
Alternate

Dr Kambiz N. Alavian, PhD, SFHEA, FLS, FRSB

Faculty of Medicine, Department of Brain Sciences

Reader in Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 7006k.alavian Website

 
 
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Assistant

 

Mrs Hadeel Abdeen +44 (0)20 7594 7014

 
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Location

 

E507Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Jonas:2017:10.1007/978-3-319-55539-3_3,
author = {Jonas, EA and Porter, GA and Beutner, G and Mnatsakanyan, N and Park, H-A and Mehta, N and Chen, R and Alavian, KN},
booktitle = {Molecular Basis for Mitochondrial Signaling},
doi = {10.1007/978-3-319-55539-3_3},
editor = {Rostovtseva},
pages = {69--105},
publisher = {Springer International Publishing},
title = {The Mitochondrial permeability transition pore: molecular structure and function in health and disease},
url = {http://dx.doi.org/10.1007/978-3-319-55539-3_3},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Ion transport across the mitochondrial inner and outer membranes is central to mitochondrial function, including regulation of oxidative phosphorylation and cell death. Although required for ATP production by mitochondria, recent findings have confirmed that the c-subunit of the ATP synthase also houses a large conductance uncoupling channel, the mitochondrial permeability transition pore (mPTP), the persistent opening of which produces osmotic dysregulation of the inner mitochondrial membrane and cell death. This chapter will discuss recent advances in understanding the molecular components of mPTP, its regulatory mechanisms during cell death, and its function in diseases of the brain. In contrast to mitochondrial inner membrane uncoupling, enhanced coupling occurs in states of improved mitochondrial efficiency; relative closure of mPTP therefore contributes to cell functions as diverse as cardiac development and synaptic efficacy.
AU  - Jonas,EA
AU  - Porter,GA
AU  - Beutner,G
AU  - Mnatsakanyan,N
AU  - Park,H-A
AU  - Mehta,N
AU  - Chen,R
AU  - Alavian,KN
DO  - 10.1007/978-3-319-55539-3_3
EP  - 105
PB  - Springer International Publishing
PY  - 2017///
SN  - 9783319555379
SP  - 69
TI  - The Mitochondrial permeability transition pore: molecular structure and function in health and disease
T1  - Molecular Basis for Mitochondrial Signaling
UR  - http://dx.doi.org/10.1007/978-3-319-55539-3_3
UR  - https://link.springer.com/chapter/10.1007%2F978-3-319-55539-3_3
ER  -
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