Imperial College London
Alternate

Dr Kambiz N. Alavian, PhD, SFHEA, FLS, FRSB

Faculty of Medicine, Department of Brain Sciences

Reader in Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 7006k.alavian Website

 
 
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Assistant

 

Mrs Hadeel Abdeen +44 (0)20 7594 7014

 
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Location

 

E507Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Licznerski:2015:10.1371/journal.pbio.1002282,
author = {Licznerski, P and Duric, V and Banasr, M and Alavian, KN and Ota, KT and Kang, HJ and Jonas, EA and Ursano, R and Krystal, JH and Duman, RS},
doi = {10.1371/journal.pbio.1002282},
journal = {PLOS Biology},
title = {Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress},
url = {http://dx.doi.org/10.1371/journal.pbio.1002282},
volume = {13},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Exposure to extreme stress can trigger the development of major depressive disorder(MDD) as well as post-traumatic stress disorder (PTSD). The molecular mechanisms underlyingthe structural and functional alterations within corticolimbic brain regions, including theprefrontal cortex (PFC) and amygdala of individuals subjected to traumatic stress, remainunknown. In this study, we show that serum and glucocorticoid regulated kinase 1 (SGK1)expression is down-regulated in the postmortem PFC of PTSD subjects. Furthermore, wedemonstrate that inhibition of SGK1 in the rat medial PFC results in helplessness- andanhedonic-like behaviors in rodent models. These behavioral changes are accompanied byabnormal dendritic spine morphology and synaptic dysfunction. Together, the results areconsistent with the possibility that altered SGK1 signaling contributes to the behavioral andmorphological phenotypes associated with traumatic stress pathophysiology.
AU  - Licznerski,P
AU  - Duric,V
AU  - Banasr,M
AU  - Alavian,KN
AU  - Ota,KT
AU  - Kang,HJ
AU  - Jonas,EA
AU  - Ursano,R
AU  - Krystal,JH
AU  - Duman,RS
DO  - 10.1371/journal.pbio.1002282
PY  - 2015///
SN  - 1545-7885
TI  - Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress
T2  - PLOS Biology
UR  - http://dx.doi.org/10.1371/journal.pbio.1002282
UR  - http://hdl.handle.net/10044/1/28514
VL  - 13
ER  -
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