Imperial College London
Alternate

Dr Kambiz N. Alavian, PhD, SFHEA, FLS, FRSB

Faculty of Medicine, Department of Brain Sciences

Reader in Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 7006k.alavian Website

 
 
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Assistant

 

Mrs Hadeel Abdeen +44 (0)20 7594 7014

 
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Location

 

E507Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Niu:2017:10.1007/s00239-017-9819-3,
author = {Niu, Y and Moghimyfiroozabad, S and Safaie, S and Yang, Y and Jonas, EA and Alavian, KN},
doi = {10.1007/s00239-017-9819-3},
journal = {Journal of Molecular Evolution},
pages = {219--233},
title = {Phylogenetic Profiling of Mitochondrial Proteins and Integration Analysis of Bacterial Transcription Units Suggest Evolution of F1Fo ATP Synthase from Multiple Modules},
url = {http://dx.doi.org/10.1007/s00239-017-9819-3},
volume = {85},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ATP synthase is a complex universal enzyme responsible for ATP synthesis across all kingdoms of life. The F-type ATPsynthase has been suggested to have evolved from two functionally independent, catalytic (F1) and membrane bound (Fo),ancestral modules. While the modular evolution of the synthase is supported by studies indicating independent assembly ofthe two subunits, the presence of intermediate assembly products suggests a more complex evolutionary process. We analyzedthe phylogenetic profiles of the human mitochondrial proteins and bacterial transcription units to gain additional insight intothe evolution of the F-type ATP synthase complex. In this study, we report the presence of intermediary modules based on thephylogenetic profiles of the human mitochondrial proteins. The two main intermediary modules comprise the α3β3 hexamerin the F1 and the c-subunit ring in the Fo. A comprehensive analysis of bacterial transcription units of F1Fo ATP synthaserevealed that while a long and constant order of F1Fo ATP synthase genes exists in a majority of bacterial genomes, highlyconserved combinations of separate transcription units are present among certain bacterial classes and phyla. Based on ourfindings, we propose a model that includes the involvement of multiple modules in the evolution of F1Fo ATP synthase. Thecentral and peripheral stalk subunits provide a link for the integration of the F1/Fo modules.
AU  - Niu,Y
AU  - Moghimyfiroozabad,S
AU  - Safaie,S
AU  - Yang,Y
AU  - Jonas,EA
AU  - Alavian,KN
DO  - 10.1007/s00239-017-9819-3
EP  - 233
PY  - 2017///
SN  - 1432-1432
SP  - 219
TI  - Phylogenetic Profiling of Mitochondrial Proteins and Integration Analysis of Bacterial Transcription Units Suggest Evolution of F1Fo ATP Synthase from Multiple Modules
T2  - Journal of Molecular Evolution
UR  - http://dx.doi.org/10.1007/s00239-017-9819-3
UR  - http://hdl.handle.net/10044/1/55907
VL  - 85
ER  -
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