Imperial College London

Dr Kofi A Anie MBE

Faculty of MedicineSchool of Public Health

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 8453 2060k.anie Website

 
 
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Location

 

Central Middlesex HospitalCentral Middlesex Hospital

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Summary

 

Publications

Citation

BibTex format

@article{Chinegwundoh:2020:10.1002/14651858.CD004198.pub4,
author = {Chinegwundoh, FI and Smith, S and Anie, KA},
doi = {10.1002/14651858.CD004198.pub4},
journal = {Cochrane Database Syst Rev},
pages = {CD004198--CD004198},
title = {Treatments for priapism in boys and men with sickle cell disease.},
url = {http://dx.doi.org/10.1002/14651858.CD004198.pub4},
volume = {4},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: Sickle cell disease comprises a group of genetic haemoglobin disorders. The predominant symptom associated with sickle cell disease is pain resulting from the occlusion of small blood vessels by abnormally 'sickle-shaped' red blood cells. There are other complications, including chronic organ damage and prolonged painful erection of the penis, known as priapism. Severity of sickle cell disease is variable, and treatment is usually symptomatic. Priapism affects up to half of all men with sickle cell disease, however, there is no consistency in treatment. We therefore need to know the best way of treating this complication in order to offer an effective interventional approach to all affected individuals. This is an update of a previously published review. OBJECTIVES: To assess the benefits and risks of different treatments for stuttering (repeated short episodes) and fulminant (lasting for six hours or more) priapism in sickle cell disease. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Haemoglobinopathies Trials Register, which comprises references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. We also searched trial registries. Date of the most recent search of the Group's Haemoglobinopathies Trials Register: 09 September 2019. Date of most recent search of trial registries and of Embase: 01 October 2019. SELECTION CRITERIA: All randomised or quasi-randomised controlled trials comparing non-surgical or surgical treatment with placebo or no treatment, or with another intervention for stuttering or fulminant priapism. DATA COLLECTION AND ANALYSIS: The authors independently extracted data and assessed the risk of bias of the trials. MAIN RESULTS: Three trials with 102 participants were identified and met the criteria for inclusion in this review. These trials compared stilboestrol to placebo, sildenafil to placebo and a four
AU - Chinegwundoh,FI
AU - Smith,S
AU - Anie,KA
DO - 10.1002/14651858.CD004198.pub4
EP - 004198
PY - 2020///
SP - 004198
TI - Treatments for priapism in boys and men with sickle cell disease.
T2 - Cochrane Database Syst Rev
UR - http://dx.doi.org/10.1002/14651858.CD004198.pub4
UR - https://www.ncbi.nlm.nih.gov/pubmed/32251534
VL - 4
ER -