Imperial College London
Dr Kofi A Anie MBE

Dr Kofi A Anie MBE

Faculty of Medicine, Faculty of Medicine Centre

 
 
 
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Contact

 

+44 (0)20 8453 2060k.anie Website

 
 
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Location

 

Central Middlesex HospitalCentral Middlesex Hospital

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Summary

 

Publications

Citation

BibTex format

@article{Anie:2017:10.1136/bmjopen-2017-016727,
author = {Anie, KA and Paintsil, V and Owusu-Dabo, E and Ansong, D and Osei-Akoto, A and Ohene-Frempong, K and Aikins, Amissah K and Addofoh, N and Bonwin, Ackah E and Owusu-Ansah, AT and Ofori-Acquah, SF},
doi = {10.1136/bmjopen-2017-016727},
journal = {BMJ Open},
title = {Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana},
url = {http://dx.doi.org/10.1136/bmjopen-2017-016727},
volume = {7},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction Sickle cell disease is highly prevalent in Africa with a significant public health burden. Nonetheless, morbidity and mortality in sickle cell disease that result from the progression of organ damage is not well understood. The Organ Damage in Sickle Cell Disease Study (ORDISS) is designed as a longitudinal cohort study to provide critical insight into cellular and molecular pathogenesis of chronic organ damage for the development of future innovative treatment.Methods and analysis ORDISS aims to recruit children aged 0–15 years who attend the Kumasi Centre for Sickle Cell Disease based at the Komfo Anokye Teaching Hospital in Kumasi, Ghana. Consent is obtained to collect blood and urine samples from the children during specified clinic visits and hospitalisations for acute events, to identify candidate and genetic markers of specific organ dysfunction and end-organ damage, over a 3 year period. In addition, data concerning clinical history and complications associated with sickle cell disease are collected. Samples are stored in biorepositories and analysed at the Kumasi Centre for Collaborative Research in Tropical Medicine, Ghana and the Centre for Translational and International Haematology, University of Pittsburgh, USA. Appropriate statistical analyses will be performed on the data acquired.Ethics and dissemination Research ethics approval was obtained at all participating sites. Results of the study will be submitted for publication in peer-reviewed journals, and the key findings presented at national and international conferences.
AU  - Anie,KA
AU  - Paintsil,V
AU  - Owusu-Dabo,E
AU  - Ansong,D
AU  - Osei-Akoto,A
AU  - Ohene-Frempong,K
AU  - Aikins,Amissah K
AU  - Addofoh,N
AU  - Bonwin,Ackah E
AU  - Owusu-Ansah,AT
AU  - Ofori-Acquah,SF
DO  - 10.1136/bmjopen-2017-016727
PY  - 2017///
SN  - 2044-6055
TI  - Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2017-016727
UR  - http://hdl.handle.net/10044/1/49900
VL  - 7
ER  -
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