Imperial College London
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Dr Kieran Bates

Faculty of Medicine, School of Public Health

Visiting Researcher
 
 
 
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Contact

 

k.bates14

 
 
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Location

 

VC9Variety Club WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bates:2018:10.1038/s41467-018-02967-w,
author = {Bates, K and Clare, F and O'Hanlon, S and Bosch, J and Brookes, L and McLaughlin, E and Daniel, O and Garner, T and Fisher, M and Harrison, X},
doi = {10.1038/s41467-018-02967-w},
journal = {Nature Communications},
title = {Amphibian chytridiomycosis outbreak dynamics are linked with host skin bacterial community structure},
url = {http://dx.doi.org/10.1038/s41467-018-02967-w},
volume = {9},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Host-associated microbes are vital for combatting infections and maintaining health. In amphibians, certain skin-associated bacteria inhibit the fungal pathogen Batrachochytrium dendrobatidis (Bd), yet our understanding of host microbial ecology and its role in disease outbreaks is limited. We sampled skin-associated bacteria and Bd from Pyrenean midwife toad populations exhibiting enzootic or epizootic disease dynamics. We demonstrate that bacterial communities differ between life stages with few shared taxa, indicative of restructuring at metamorphosis. We detected a significant effect of infection history on metamorph skin microbiota, with reduced bacterial diversity in epizootic populations and differences in community structure and predicted function. Genome sequencing of Bd isolates supports a single introduction to the Pyrenees and reveals no association between pathogen genetics and epidemiological trends. Our findings provide an ecologically relevant insight into the microbial ecology of amphibian skin and highlight the relative importance of host microbiota and pathogen genetics in predicting disease outcome.
AU  - Bates,K
AU  - Clare,F
AU  - O'Hanlon,S
AU  - Bosch,J
AU  - Brookes,L
AU  - McLaughlin,E
AU  - Daniel,O
AU  - Garner,T
AU  - Fisher,M
AU  - Harrison,X
DO  - 10.1038/s41467-018-02967-w
PY  - 2018///
SN  - 2041-1723
TI  - Amphibian chytridiomycosis outbreak dynamics are linked with host skin bacterial community structure
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-018-02967-w
UR  - http://hdl.handle.net/10044/1/54806
VL  - 9
ER  -
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