Imperial College London
Alternate

Dr Kelsey Case

Faculty of Medicine, School of Public Health

Honorary Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 1524k.case

 
 
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Location

 

LG33BPraed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stover:2014:10.1371/journal.pone.0111956,
author = {Stover, J and Hallett, TB and Wu, Z and Warren, M and Gopalappa, C and Pretorius, C and Ghys, PD and Montaner, J and Schwartlander, B},
doi = {10.1371/journal.pone.0111956},
journal = {PLOS One},
title = {How Can We Get Close to Zero? The Potential Contribution of Biomedical Prevention and the Investment Framework towards an Effective Response to HIV},
url = {http://dx.doi.org/10.1371/journal.pone.0111956},
volume = {9},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: In 2011 an Investment Framework was proposed that described how the scale-up of key HIV interventionscould dramatically reduce new HIV infections and deaths in low and middle income countries by 2015. This frameworkincluded ambitious coverage goals for prevention and treatment services resulting in a reduction of new HIV infections bymore than half. However, it also estimated a leveling in the number of new infections at about 1 million annually after 2015.Methods: We modeled how the response to AIDS can be further expanded by scaling up antiretroviral treatment (ART)within the framework provided by the 2013 WHO treatment guidelines. We further explored the potential contributions ofnew prevention technologies: ‘Test and Treat’, pre-exposure prophylaxis and an HIV vaccine.Findings: Immediate aggressive scale up of existing approaches including the 2013 WHO guidelines could reduce newinfections by 80%. A ‘Test and Treat’ approach could further reduce new infections. This could be further enhanced by afuture highly effective pre-exposure prophylaxis and an HIV vaccine, so that a combination of all four approaches couldreduce new infections to as low as 80,000 per year by 2050 and annual AIDS deaths to 260,000.Interpretation: In a set of ambitious scenarios, we find that immediate implementation of the 2013 WHO antiretroviraltherapy guidelines could reduce new HIV infections by 80%. Further reductions may be achieved by moving to a ‘Test andTreat’ approach, and eventually by adding a highly effective pre-exposure prophylaxis and an HIV vaccine, if they becomeavailable.
AU  - Stover,J
AU  - Hallett,TB
AU  - Wu,Z
AU  - Warren,M
AU  - Gopalappa,C
AU  - Pretorius,C
AU  - Ghys,PD
AU  - Montaner,J
AU  - Schwartlander,B
DO  - 10.1371/journal.pone.0111956
PY  - 2014///
SN  - 1932-6203
TI  - How Can We Get Close to Zero? The Potential Contribution of Biomedical Prevention and the Investment Framework towards an Effective Response to HIV
T2  - PLOS One
UR  - http://dx.doi.org/10.1371/journal.pone.0111956
UR  - http://hdl.handle.net/10044/1/27648
VL  - 9
ER  -
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