Karyn Chappell is a Postdoctoral Scholar in Orthopaedic Surgery currently at Stanford University and a Honorary Research Associate at Imperial College London in the Department of Surgery.
Karyn graduated from King’s College London and rapidly found her niche working within the modality of MRI. Consolidating her understanding with a postgraduate qualification in MRI from Anglia Ruskin University. She has worked in numerous settings, including research and clinical trials, as well as private and NHS clinical work.
Her position as a research assistant on the transverse field MRI or "magic angle" scanner project had her developing the Magic Angle Directional Imaging (MADI) technique to scan patients when B0 moves. She worked with many varied disciplines to assist in developing this novel scanner.
Her PhD under the supervision of Dr Catherine Van Der Straeten, Professor Wladyslaw Gedroyc and Professor Donald McRobbie was associated with developing the applications for use on this novel scanner. For example, using the magic angle effect to visualise and quantify the health of the anterior cruciate ligament (ACL) of patients prior to unicondylar knee replacement. She hopes to continue to explore the potential of the magic angle effect in non-invasively detecting collagen changes that indicate cartilage damage in knees which have differing stages of osteoarthritis.
In her Postdoctoral position at Stanford University she is continuing to investigate the knee after ACL reconstruction to assess cartilage thickness and damage with qDESS and cones T2* UTE sequences. She is also developing a 'muscle quality' MRI protocol the measure and quantify some of the factors that change in the thigh muscles after ACLR. The Orthopaedic Surgery group hope to develop interventions that could reduce the early changes to the VMO muscle.
et al., 2019, Detection of maturity and ligament injury using magic angle directional imaging, Magnetic Resonance in Medicine, Vol:82, ISSN:0740-3194, Pages:1041-1054
et al., 2016, Development of Early Adiposity in Infants of Mothers With Gestational Diabetes Mellitus, Diabetes Care, Vol:39, ISSN:0149-5992, Pages:1045-1051
et al., 2013, Avoiding sedation in research MRI and spectroscopy in infants: our approach, success rate and prevalence of incidental findings, Archives of Disease in Childhood-fetal and Neonatal Edition, Vol:98, ISSN:1359-2998, Pages:F267-F268
et al., 2010, A method for measuring the cross sectional area of the anterior portion of the optic nerve in vivo using a fast 3D MRI sequence., J Magn Reson Imaging, Vol:31, Pages:1486-1491
et al., 2005, Magnetic resonance imaging of cortical bone with ultrashort TE pulse sequences, Magnetic Resonance Imaging, Vol:23, ISSN:0730-725X, Pages:611-618