Imperial College London
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DrKarynChappell

Faculty of Engineering, Department of Mechanical Engineering

Research Associate
 
 
 
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Contact

 

k.chappell Website

 
 
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Location

 

Lab 122 / Office 774City and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chappell:2019:10.1002/mrm.27794,
author = {Chappell, K and Brujic, D and Van, Der Straeten C and Meeson, R and Gedroyc, W and McRobbie, D and Ristic, M},
doi = {10.1002/mrm.27794},
journal = {Magnetic Resonance in Medicine},
pages = {1041--1054},
title = {Detection of maturity and ligament injury using magic angle directional imaging},
url = {http://dx.doi.org/10.1002/mrm.27794},
volume = {82},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Purpose: To investigate whether magnetic field–related anisotropies of collagen may be correlated with postmortem findings in animal models.Methods: Optimized scan planning and new MRI dataprocessing methods were proposed and analyzed using Monte Carlo simulations. Six caprine and 10 canine knees were scanned at various orientations to the main magnetic field. Image intensities in segmented voxels were used to compute the orientation vectors of the collagen fibers. Vector field and tractography plots were computed. The Alignment Index was defined as a measure of orientation distribution. The knees were subsequently assessed by a specialist orthopedic veterinarian, who gave a pathological diagnosis after having dissected and photographed the joints.Results: Using 50% less scans than reported previously can lead to robust calculation of fiber orientations in the presence of noise, with much higher accuracy. The 6 caprine knees were found to range from very immature (< 3 months) to very mature (> 3 years). Mature specimens exhibited significantly more aligned collagen fibers in their patella tendons compared with the immature ones. In 2 of the 10 canine knees scanned, partial cranial caudal ligament tears were identified from MRI and subsequently confirmed with encouragingly high consistency of tractography, Alignment Index, and dissection results.Conclusion: This method can be used to detect injury such as partial ligament tears, and to visualize maturityrelated changes in the collagen structure of tendons. It can provide the basis for new, noninvasive diagnostic tools in combination with new scanner configurations that allow lessrestricted field orientations.
AU  - Chappell,K
AU  - Brujic,D
AU  - Van,Der Straeten C
AU  - Meeson,R
AU  - Gedroyc,W
AU  - McRobbie,D
AU  - Ristic,M
DO  - 10.1002/mrm.27794
EP  - 1054
PY  - 2019///
SN  - 0740-3194
SP  - 1041
TI  - Detection of maturity and ligament injury using magic angle directional imaging
T2  - Magnetic Resonance in Medicine
UR  - http://dx.doi.org/10.1002/mrm.27794
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.27794
UR  - http://hdl.handle.net/10044/1/70197
VL  - 82
ER  -
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