The aim of my research is to investigate the cellular and molecular mechanisms responsible for neutrophil retention in the microcapillary of the lung and neutrophil clearance in the spleen. Cutting edge microscopy techniques are used to take a novel and innovative look at these fundamental mechanisms highly relevant to many neutrophilic diseases.
I completed by BSc and MRes in Molecular Biology at University of Turin, Italy in 2004 and subsequently undertook a PhD in Immunology and Molecular Pathology within the group of Dr Nancy Hogg (Leukocyte Adhesion Laboratory) at CRUK, London where I investigated how neutrophil chemoattractant KC and MIP-2 are newly synthesized by macrophages making use of distinct TLR signalling pathways and how macrophages and mast cells synergise in the process of neutrophil migration during LPS infection.
I continued my research in the Leukocyte Adhesion Laboratory studying the effect of G-CSF and KC on the process of neutrophil mobilization from the bone marrow; the role of integrin in neutrophil and T cell recruitment to lung during Streptococcus Pneumoniae infection; also the functional role of S100a9 protein in the recruitment of neutrophils during pneumococcal pneumonia infection.
In 2015, I joined the Inflammation, Repair and Development Section within the National Heart and Lung Institute (NHLI) at Imperial College London as Research Associate in Dr Leo Carlin Laboratory. In 2016 I was awarded a Re-entry Wellcome Trust Fellowship investigating the cellular and molecular mechanisms of neutrophil homeostasis in the lung and spleen.
De Filippo K, Rankin SM, 2018, CXCR4, the master regulator of neutrophil trafficking in homoeostasis and disease., European Journal of Clinical Investigation, Vol:48, ISSN:0014-2972
et al., 2017, Inhibition of endosteal vascular niche remodeling rescues hematopoietic stem cell loss in AML, Cell Stem Cell, Vol:22, ISSN:1875-9777, Pages:64-77.e6
et al., 2014, A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia, The Faseb Journal, Vol:28, ISSN:0892-6638, Pages:3600-3608
et al., 2013, Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation, Blood, Vol:121, ISSN:0006-4971, Pages:4930-4937
et al., 2011, G-CSF–mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands, Blood, Vol:117, ISSN:0006-4971, Pages:4349-4357