Imperial College London

ProfessorKurtDrickamer

Faculty of Natural SciencesDepartment of Life Sciences

Chair in Biochemistry
 
 
 
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Contact

 

+44 (0)20 7594 5282k.drickamer

 
 
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Location

 

606Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

51 results found

Taylor ME, Drickamer K, 2011, Introduction to Glycobiology, Third Edition, Publisher: Oxford University Press, ISBN: 978-0-19-956911-3

Book

Coombs PJ, Harrison R, Pemberton S, Quintero-Martinez A, Parry S, Haslam SM, Dell A, Taylor ME, Drickamer Ket al., 2010, Identification of Novel Contributions to High-affinity Glycoprotein-Receptor Interactions using Engineered Ligands, JOURNAL OF MOLECULAR BIOLOGY, Vol: 396, Pages: 685-696, ISSN: 0022-2836

Journal article

Powlesland AS, Quintero-Martinez A, Lim PG, Pipirou Z, Taylor ME, Drickamer Ket al., 2010, ENGINEERED CARBOHYDRATE-RECOGNITION DOMAINS FOR GLYCOPROTEOMIC ANALYSIS OF CELL SURFACE GLYCOSYLATION AND LIGANDS FOR GLYCAN-BINDING RECEPTORS, METHODS IN ENZYMOLOGY, VOL 480: GLYCOBIOLOGY, Vol: 480, Pages: 165-179, ISSN: 0076-6879

Journal article

Feinberg H, Tso CKW, Taylor ME, Drickamer K, Weis WIet al., 2009, Segmented Helical Structure of the Neck Region of the Glycan-Binding Receptor DC-SIGNR, JOURNAL OF MOLECULAR BIOLOGY, Vol: 394, Pages: 613-620, ISSN: 0022-2836

Journal article

Taylor ME, Drickamer K, 2009, Structural insights into what glycan arrays tell us about how glycan-binding proteins interact with their ligands, GLYCOBIOLOGY, Vol: 19, Pages: 1155-1162, ISSN: 0959-6658

Journal article

Tanne A, Ma B, Boudou F, Tailleux L, Botella H, Badell E, Levillain F, Taylor ME, Drickamer K, Nigou J, Dobos KM, Puzo G, Vestweber D, Wild MK, Marcinko M, Sobieszczuk P, Stewart L, Lebus D, Gicquel B, Neyrolles Oet al., 2009, A murine DC-SIGN homologue contributes to early host defense against <i>Mycobacterium tuberculosis</i>, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 206, Pages: 2205-2220, ISSN: 0022-1007

Journal article

Powlesland AS, Hitchen PG, Parry S, Graham SA, Marcela Barrio M, Teresa Elola M, Mordoh J, Dell A, Drickamer K, Taylor MEet al., 2009, Targeted glycoproteomic identification of cancer cell glycosylation, GLYCOBIOLOGY, Vol: 19, Pages: 899-909, ISSN: 0959-6658

Journal article

Menon S, Rosenberg K, Graham SA, Ward EM, Taylor ME, Drickamer K, Leckband DEet al., 2009, Binding-site geometry and flexibility in DC-SIGN demonstrated with surface force measurements, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 11524-11529, ISSN: 0027-8424

Journal article

Graham SA, Jegouzo SAF, Yan S, Powlesland AS, Brady JP, Taylor ME, Drickamer Ket al., 2009, Prolectin, a Glycan-binding Receptor on Dividing B Cells in Germinal Centers, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 284, Pages: 18537-18544

Journal article

Yu QD, Oldring AP, Powlesland AS, Tso CKW, Yang C, Drickamer K, Taylor MEet al., 2009, Autonomous Tetramerization Domains in the Glycan-binding Receptors DC-SIGN and DC-SIGNR, JOURNAL OF MOLECULAR BIOLOGY, Vol: 387, Pages: 1075-1080, ISSN: 0022-2836

Journal article

Powlesland AS, Fisch T, Taylor ME, Smith DF, Tissot B, Dell A, Poehlmann S, Drickamer Ket al., 2008, A novel mechanism for LSECtin binding to Ebola virus surface glycoprotein through truncated glycans, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 593-602

Journal article

Taylor ME, Drickarner K, 2007, Paradigms for glycan-binding receptors in cell adhesion, CURRENT OPINION IN CELL BIOLOGY, Vol: 19, Pages: 572-577, ISSN: 0955-0674

Journal article

Powlesland AS, Ward EM, Sadhu SK, Guo Y, Taylor ME, Drickamer Ket al., 2006, Erratum: Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins. (Journal of Biological Chemistry (2006) 281 (20440-20449)), Journal of Biological Chemistry, Vol: 281, ISSN: 0021-9258

Journal article

Drickamer K, Taylor ME, 2006, Recognizing glycans: mammalian sugar-binding receptors, The Biochemist, Vol: 28, Pages: 8-12

Journal article

Maureen E Taylor, Kurt Drickamer, 2006, Introduction to Glycobiology, Oxford, Publisher: Oxford University Press, ISBN: 9780199282784

Book

Coombs PJ, Graham SA, Drickamer K, Taylor MEet al., 2005, Selective binding of the scavenger receptor C-type lectin to Lewis<SUP>x</SUP> trisaccharide and related glycan ligands, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 22993-22999

Journal article

Feinberg H, Guo Y, Mitchell DA, Drickamer K, Weis WIet al., 2005, Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 1327-1335, ISSN: 0021-9258

Journal article

Frison N, Taylor ME, Soilleux E, Bousser MT, Mayer R, Monsigny M, Drickamer K, Roche ACet al., 2003, Erratum: Oligolysine-based oligosaccharide clusters. Selective recognition and endocytosis by the mannose receptor and dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (Journal of Biological Chemistry (2003) 278 (23922-23929)), Journal of Biological Chemistry, Vol: 278, ISSN: 0021-9258

Journal article

Weis WI, Drickamer K, 1996, STRUCTURAL BASIS OF LECTIN-CARBOHYDRATE RECOGNITION, Annual Review of Biochemistry, Vol: 65, Pages: 441-473, ISSN: 0066-4154

<jats:p> Lectins are responsible for cell surface sugar recognition in bacteria, animals, and plants. Examples include bacterial toxins; animal receptors that mediate cellcell interactions, uptake of glycoconjugates, and pathogen neutralization; and plant toxins and mitogens. The structural basis for selective sugar recognition by members of all of these groups has been investigated by x-ray crystallography. Mechanisms for sugar recognition have evolved independently in diverse protein structural frameworks, but share some key features. Relatively low affinity binding sites for monosaccharides are formed at shallow indentations on protein surfaces. Selectivity is achieved through a combination of hydrogen bonding to the sugar hydroxyl groups with van der Waals packing, often including packing of a hydrophobic sugar face against aromatic amino acid side chains. Higher selectivity of binding is achieved by extending binding sites through additional direct and water-mediated contacts between oligosaccharides and the protein surface. Dramatically increased affinity for oligosaccharides results from clustering of simple binding sites in oligomers of the lectin polypeptides. The geometry of such oligomers helps to establish the ability of the lectins to distinguish surface arrays of polysaccharides in some instances and to crosslink glycoconjugates in others. </jats:p>

Journal article

Drickamer K, 1993, Biology of Animal Lectins, Annual Review of Cell and Developmental Biology, Vol: 9, Pages: 237-264, ISSN: 1081-0706

Journal article

CZERWINSKI E, 1972, Crystallographic study of cytochrome b562 from Escherichia coli*1, Journal of Molecular and Cellular Cardiology, Vol: 71, Pages: 819-820, ISSN: 0022-2828

Journal article

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