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@article{Taylor:2019:10.1111/febs.14759,
author = {Taylor, ME and Drickamer, K},
doi = {10.1111/febs.14759},
journal = {FEBS Journal},
pages = {1800--1814},
title = {Mammalian sugar-binding receptors: known functions and unexplored roles},
url = {http://dx.doi.org/10.1111/febs.14759},
volume = {286},
year = {2019}
}

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TY  - JOUR
AB  - Mammalian glycan-binding receptors, sometimes known as lectins, interact withglycans, the oligosaccharide portions ofendogenous mammalian glycoproteins and glycolipids as well as sugars on the surfaces of microbes.Thesereceptors guide glycoproteins out of and back into cells, facilitate communication between cells through both adhesion and signaling, and allow the innate immune system to respond quickly to viral, fungal, bacterial,and parasiticpathogens.For many of the roughly one hundred glycan-binding receptors that are known in humans,there aregood descriptions of what types of glycans they bind and how selectivity for these ligands is achievedat the molecular level.In some cases, there is also comprehensive evidencefor the roles thatthe receptors playat the cellular and organismal levels. In addition to highlighting these well-understood paradigms for glycan-binding receptors, this review will suggest where gaps remain in our understandingof the physiological functions that they can serve.
AU  - Taylor,ME
AU  - Drickamer,K
DO  - 10.1111/febs.14759
EP  - 1814
PY  - 2019///
SN  - 1742-464X
SP  - 1800
TI  - Mammalian sugar-binding receptors: known functions and unexplored roles
T2  - FEBS Journal
UR  - http://dx.doi.org/10.1111/febs.14759
UR  - https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.14759
UR  - http://hdl.handle.net/10044/1/66105
VL  - 286
ER  -

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