Imperial College London
Alternate

ProfessorKurtDrickamer

Faculty of Natural Sciences, Department of Life Sciences

Chair in Biochemistry
 
 
 
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Contact

 

+44 (0)20 7594 5282k.drickamer

 
 
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Location

 

606Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rambaruth:2015:10.3390/molecules20046670,
author = {Rambaruth, ND and Jégouzo, SA and Marlor, H and Taylor, ME and Drickamer, K},
doi = {10.3390/molecules20046670},
journal = {Molecules},
pages = {6670--6682},
title = {Mouse mincle: characterization as a model for human mincle and evolutionary implications.},
url = {http://dx.doi.org/10.3390/molecules20046670},
volume = {20},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mincle, the macrophage-inducible C-type lectin also known as CLEC-4E, binds to the mycobacterial glycolipid trehalose dimycolate and initiates a signaling cascade by serving as a receptor for Mycobacterium tuberculosis and other pathogenic mycobacterial species. Studies of the biological functions of human mincle often rely on mouse models, based on the assumption that the biological properties of the mouse receptor mimic those of the human protein. Experimental support for this assumption has been obtained by expression of the carbohydrate-recognition domain of mouse mincle and characterization of its interaction with small molecule analogs of trehalose dimycolate. The results confirm that the ligand-binding properties of mouse mincle closely parallel those of the human receptor. These findings are consistent with the conservation of key amino acid residues that have been shown to form the ligand-binding site in human and cow mincle. Sequence alignment reveals that these residues are conserved in a wide range of mammalian species, suggesting that mincle has a conserved function in binding ligands that may include endogenous mammalian glycans or pathogen glycans in addition to trehalose dimycolate.
AU  - Rambaruth,ND
AU  - Jégouzo,SA
AU  - Marlor,H
AU  - Taylor,ME
AU  - Drickamer,K
DO  - 10.3390/molecules20046670
EP  - 6682
PY  - 2015///
SN  - 1420-3049
SP  - 6670
TI  - Mouse mincle: characterization as a model for human mincle and evolutionary implications.
T2  - Molecules
UR  - http://dx.doi.org/10.3390/molecules20046670
UR  - http://hdl.handle.net/10044/1/22085
VL  - 20
ER  -
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