Imperial College London
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DrKimberleyFoley

Faculty of Medicine, School of Public Health

Research Associate
 
 
 
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Contact

 

k.foley

 
 
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Location

 

319Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Arshad:2019:10.2196/preprints.14216,
author = {Arshad, Z and Alturkistani, A and Brindley, D and Lam, C and Foley, K and Meinert, E},
doi = {10.2196/preprints.14216},
publisher = {JMIR Publications},
title = {Tools for the diagnosis of herpes simplex virus 1/2: systematic review of studies published between 2012 and 2018 (Preprint)},
url = {http://dx.doi.org/10.2196/preprints.14216},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Background:Herpes simplex virus (HSV)-1 and HSV-2 are common infections affecting the global population, with HSV-1 estimated to affect 67% of the global population. HSV can have rare but severe manifestations, such as encephalitis and neonatal herpes, necessitating the use of reliable and accurate diagnostic tools for the detection of the viruses. Currently used HSV diagnostic tools require highly specialized skills and availability of a laboratory setting but may lack sensitivity. The numerous recently developed HSV diagnostic tools need to be identified and compared in a systematic way to make the best decision about which diagnostic tool to use. The diagnosis of HSV is essential for prompt treatment with antivirals. To select the best test for a patient, knowledge of the performance and limitations of each test is critical.Objective:This systematic review has summarized recent studies evaluating HSV-1 and HSV-2 diagnostic tools.Methods:Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, selection criteria, data extraction, and data analysis were determined before the commencement of the study. Studies assessing the specificity/sensitivity of HSV-1 or HSV-2 diagnostic tools published between 2012 and 2018 were included. Quality assessment of included studies was performed using the quality assessment of diagnostic accuracy studies (QUADAS-2) tool.Results:Searches of the PubMed database yielded 264 studies; 11 studies included 11 molecular assays, and 8 studies included 19 different serological assays for the detection of HSV-1, HSV-2, or both. A greater proportion of molecular assay–based tools are being developed by commercial entities. Studies that tested molecular assays mostly focused on cutaneous and mucosal HSV infections (n=13); 2 studies focused on ocular disease, whereas only 1 study focused on the central nervous system manifestations. The Simplexa HSV 1 & 2 Direct is currently the only Food and Drug Ad
AU  - Arshad,Z
AU  - Alturkistani,A
AU  - Brindley,D
AU  - Lam,C
AU  - Foley,K
AU  - Meinert,E
DO  - 10.2196/preprints.14216
PB  - JMIR Publications
PY  - 2019///
TI  - Tools for the diagnosis of herpes simplex virus 1/2: systematic review of studies published between 2012 and 2018 (Preprint)
UR  - http://dx.doi.org/10.2196/preprints.14216
UR  - http://hdl.handle.net/10044/1/87924
ER  -
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