Imperial College London


Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism



+44 (0)20 3313 2156k.g.murphy




6N3bCommonwealth BuildingHammersmith Campus





My research focuses on the role of the hypothalamus in the control of energy homeostasis and reproduction. Both of these physiological roles have important implications for human health. I am particularly interested in how the gut senses nutritional status and signals to appetite centres of the brain such as the hypothalamus and brain stem to regulate food intake. I am also interested in how central hypothalamic neuropeptide circuits act to control body weight and reproductive function.

I have won funding from sources including the BBSRC, the MRC, the Technology Strategy Board, the Society for Endocrinology, the British Society for Neuroendocrinology, the British Pharmacological Society and the NC3Rs. I have successfully supervised more than thirty PhD students to completion. I am an honorary fellow of the Royal College of Physicians, Director of Postgraduate Studies (Research) for the Department of Medicine, and Admissions Tutor for the Faculty of Medicine with particular responsibility for widening participation. 



Alkaf B, Siddiqui M, Ali T, et al., 2022, Ramadan Fasting and Changes in Thyroid Function in Hypothyroidism: Identifying Patients at Risk., Thyroid, Vol:32, Pages:368-375

Frampton J, Murphy K, Frost G, et al., 2021, Higher dietary fibre intake is associated with increased skeletal muscle mass and strength in adults aged 40 years and older, Journal of Cachexia, Sarcopenia and Muscle, Vol:12, ISSN:2190-6009, Pages:2134-2144

Frampton J, Cobbold B, Nozdrin M, et al., 2021, The effect of a single bout of continuous aerobic exercise on glucose, insulin and glucagon concentrations compared to resting conditions in healthy adults: a systematic review, meta-analysis and meta-regression, Sports Medicine, Vol:51, ISSN:0112-1642, Pages:1949-1966

Salem V, McDonagh J, Avis E, et al., 2021, Scientific medical conferences can be easily modified to improve female inclusion: a prospective study., The Lancet Diabetes and Endocrinology, Vol:9, ISSN:2213-8595, Pages:556-559

Nahar LK, Murphy KG, Paterson S, 2021, Baclofen: To screen or not to screen in postmortem blood?, Journal of Analytical Toxicology, Vol:45, ISSN:0146-4760, Pages:612-618

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