Summary
My research focuses on the role of the hypothalamus in the control of energy homeostasis and reproduction. Both of these physiological roles have important implications for human health. I am particularly interested in how the gut senses nutritional status and signals to appetite centres of the brain such as the hypothalamus and brain stem to regulate food intake. I am also interested in how central hypothalamic neuropeptide circuits act to control body weight and reproductive function.
I have won funding from sources including the BBSRC, the MRC, the Technology Strategy Board, the Society for Endocrinology, the British Society for Neuroendocrinology, the British Pharmacological Society and the NC3Rs. I have successfully supervised more than thirty PhD students to completion. I am an honorary fellow of the Royal College of Physicians, Director of Postgraduate Studies (Research) for the Department of Medicine, and Admissions Tutor for the Faculty of Medicine with particular responsibility for widening participation.
Publications
Journals
Frampton J, Murphy K, Frost G, et al., 2021, Higher dietary fibre intake is associated with increased skeletal muscle mass and strength in adults aged 40 years and older, Journal of Cachexia, Sarcopenia and Muscle, ISSN:2190-6009
Frampton J, Cobbold B, Nozdrin M, et al., 2021, The effect of a single bout of continuous aerobic exercise on glucose, insulin and glucagon concentrations compared to resting conditions in healthy adults: a systematic review, meta-analysis and meta-regression, Sports Medicine, Vol:51, ISSN:0112-1642, Pages:1949-1966
Salem V, McDonagh J, Avis E, et al., 2021, Scientific medical conferences can be easily modified to improve female inclusion: a prospective study., The Lancet Diabetes and Endocrinology, ISSN:2213-8595
Nahar LK, Murphy KG, Paterson S, 2021, Baclofen: To screen or not to screen in postmortem blood?, Journal of Analytical Toxicology, Vol:45, ISSN:0146-4760, Pages:612-618
Amin A, Frampton J, Liu Z, et al., 2021, Differential effects of L- and D-phenylalanine on pancreatic and gastrointestinal hormone release in humans: a randomised crossover study., Diabetes, Obesity and Metabolism: a Journal of Pharmacology and Therapeutics, Vol:23, ISSN:1462-8902, Pages:147-157