Summary
My research focuses on the role of the hypothalamus in the control of energy homeostasis and reproduction. Both of these physiological roles have important implications for human health. I am particularly interested in how the gut senses nutritional status and signals to appetite centres of the brain such as the hypothalamus and brain stem to regulate food intake. I am also interested in how central hypothalamic neuropeptide circuits act to control body weight and reproductive function.
I have won funding from sources including the BBSRC, the MRC, the Technology Strategy Board, the Society for Endocrinology, the British Society for Neuroendocrinology, the British Pharmacological Society and the NC3Rs. I have successfully supervised more than twenty PhD students to completion. I am Director of Postgraduate Studies (Research) for the Department of Medicine, and Admissions Tutor for the Faculty of Medicine with particular responsibility for widening participation.
Publications
Journals
Amin A, Frampton J, Liu Z, et al., 2021, Differential effects of L- and D-phenylalanine on pancreatic and gastrointestinal hormone release in humans: a randomised crossover study., Diabetes, Obesity and Metabolism: a Journal of Pharmacology and Therapeutics, Vol:23, ISSN:1462-8902, Pages:147-157
Dagbasi A, Lett A, Murphy K, et al., 2020, Understanding the interplay between food structure, intestinal bacterial fermentation and appetite control, Proceedings of the Nutrition Society, Vol:79, ISSN:0029-6651, Pages:514-530
Nahar LK, Murphy KG, Paterson S, 2020, Baclofen: To screen or not to screen in postmortem blood?, Journal of Analytical Toxicology, ISSN:0146-4760
Frampton J, Murphy KG, Frost G, et al., 2020, Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function, Nature Metabolism, Vol:2, ISSN:2522-5812, Pages:840-848
Martin N, Sovetkina A, Nadir R, et al., 2020, Development of autoimmune thyroid disease in multiple sclerosis patients post-alemtuzumab improves treatment response, The Journal of Clinical Endocrinology & Metabolism, Vol:105, ISSN:0021-972X, Pages:e3392-e3399