Summary
My research focuses on the role of the hypothalamus in the control of energy homeostasis and reproduction. Both of these physiological roles have important implications for human health. I am particularly interested in how the gut senses nutritional status and signals to appetite centres of the brain such as the hypothalamus and brain stem to regulate food intake. I am also interested in how central hypothalamic neuropeptide circuits act to control body weight and reproductive function.
I have won funding from sources including the BBSRC, the MRC, the Technology Strategy Board, the Society for Endocrinology, the British Society for Neuroendocrinology, the British Pharmacological Society and the NC3Rs. I have successfully supervised more than thirty PhD students to completion. I am an honorary fellow of the Royal College of Physicians, Director of Postgraduate Studies (Research) for the Department of Medicine, and Admissions Tutor for the Faculty of Medicine with particular responsibility for widening participation.
Publications
Journals
Hornos E, Pleguezuelos E, Bala L, et al., 2024, Reliability, validity and acceptability of an online clinical reasoning simulator for medical students: An international pilot., Med Teach, Pages:1-8
Alonso AM, Cork SC, Phuah P, et al., 2024, The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake, Molecular Metabolism, Vol:81, ISSN:2212-8778
Chambers E, Frampton J, Serrano-Contreras JI, et al., 2024, The impact of acute exercise on appetite regulation: Unravelling the potential involvement of gut microbial activity, The Journal of Physiology, Vol:602, ISSN:0022-3751, Pages:529-530
Frampton J, Serrano Contreras J, Garcia Perez I, et al., 2023, The metabolic interplay between dietary carbohydrate and exercise and its role in acute appetite-regulation in males: a randomised controlled study, The Journal of Physiology, Vol:601, ISSN:0022-3751, Pages:3461-3480
Ramos-Pittol J, Fernandes-Freitas I, Milona A, et al., 2023, Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice, Nature Communications, Vol:14, ISSN:2041-1723, Pages:1-10