Publications
179 results found
Ramachandran R, Bech P, Murphy KG, et al., 2010, Chromogranin A assays: Comparison of diagnostic accuracy, 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 12-12, ISSN: 0167-0115
Nijher GMK, Baxter JE, Chaudhri OB, et al., 2010, Identification of the Hormone Kisspeptin in Amniotic Fluid, CLINICAL CHEMISTRY, Vol: 56, Pages: 1029-1031, ISSN: 0009-9147
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- Citations: 3
Curtis AE, Murphy KG, Chaudhri OB, et al., 2010, Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer, ONCOLOGY REPORTS, Vol: 23, Pages: 1729-1734, ISSN: 1021-335X
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- Citations: 16
Jayasena CN, Nijher GMK, Abbara A, et al., 2010, Twice-Weekly Administration of Kisspeptin-54 for Eight Weeks Stimulates Reproductive Hormone Release in Women with Hypothalamic Amenorrhea, 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, Pages: S2527-S2527, ISSN: 0163-769X
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- Citations: 1
Addison ML, Minnion JS, Shillito JC, et al., 2010, Investigating the Metabolic Clearance and Degradation of the Anorexigenic Gut Hormone PYY3-36 as a Tool To Design Long-Acting Analogues of PYY3-36 for the Treatment of Obesity., 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, ISSN: 0163-769X
Hostomska K, Salem V, Field BCT, et al., 2010, Resistance to the Anorectic Effect of PYY3-36 during Continuous Infusion Is Independent from the Stimulation of Appetite Resulting from Weight Loss., 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, ISSN: 0163-769X
Boughton CK, Patterson M, Tadross JA, et al., 2010, The Novel Neuropeptide Alarin Stimulates Food Intake and the Reproductive Axis in Male Rats., 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, ISSN: 0163-769X
Jayasena CN, Nijher GMK, Chaudhri OB, et al., 2010, Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis, Obstetrical and Gynecological Survey, Vol: 65, Pages: 244-245, ISSN: 0029-7828
Thompson EL, Murphy KG, 2010, Modulation of the hypothalamic-pituitary-gonadal axis by selective ligands of the KISS1R, CURRENT OPINION IN INVESTIGATIONAL DRUGS, Vol: 11, Pages: 432-439, ISSN: 1472-4472
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- Citations: 2
Corander MP, Challis BG, Thompson EL, et al., 2010, The Effects of Neurokinin B upon Gonadotrophin Release in Male Rodents, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 22, Pages: 181-187, ISSN: 0953-8194
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- Citations: 56
Ashby DR, Gale DP, Busbridge M, et al., 2010, Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol: 95, Pages: 505-508, ISSN: 0390-6078
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- Citations: 138
Curtis AE, Cooke JH, Baxter JE, et al., 2010, A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10., Am J Physiol Endocrinol Metab, Vol: 298, Pages: E296-E303
The kisspeptins are neuropeptides that stimulate the hypothalamo-pituitary-gonadal (HPG) axis. The smallest endogenous kisspeptin, kisspeptin-10 (KP-10), binds to the receptor KISS1R with a similar affinity to the full-length peptide, kisspeptin-54 (KP-54), but is less effective in vivo, possibly because of increased enzymatic breakdown or clearance. The kisspeptin system may have therapeutic potential in the treatment of reproductive disorders and endocrine cancers. We have rationally modified the structure of KP-10 and tested the binding affinity of these analogs for the KISS1R. Those analogs that bound with relatively high affinity to KISS1R were tested for ability to stimulate ERK1/2 phosphorylation in vitro and for their ability to stimulate the HPG axis in vivo. One analog, [dY](1)KP-10, bound to KISS1R with lower affinity to KP-10 and exhibited similar bioactivity in vitro. However, in vivo peripheral administration of [dY](1)KP-10 increased plasma LH and testosterone more potently than KP-10 itself at 20 min postinjection in mice. In addition, 60 min postinjection, 0.15 nmol [dY](1)KP-10 significantly increased total testosterone levels in mice whereas the same dose of KP-10 had no significant effect. Should manipulation of the kisspeptin/KISS1R signaling system prove therapeutically useful, long-lasting analogs such as [dY](1)KP-10 may have greater therapeutic potential than endogenous forms of kisspeptin.
Curtis AE, Cooke JH, Baxter JE, et al., 2010, A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 298, Pages: E296-E303, ISSN: 0193-1849
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- Citations: 47
Curtis AE, Murphy KG, Chaudhri OB, et al., 2010, Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer, Oncology Reports, Vol: 23, Pages: 1729-1734, ISSN: 1021-335X
Kisspeptin, the product of the KiSS-1 gene, inhibits metastasis and stimulates the hypothalamo-pituitary-gonadal axis. Kisspeptin is therefore a putative target in the treatment of hormone-sensitive malignancies. Prostatic carcinoma remains a significant cause of mortality despite improvements in therapy. The role of kisspeptin in prostatic carcinoma remains undefined. We therefore aimed to investigate release of kisspeptin by prostatic cancer cell lines; investigate expression of KiSS-1 in human prostate tissue; investigate whether patients with prostate carcinoma have elevated plasma kisspeptin. 1) Culture medium from prostatic carcinoma cell lines LNCaP, DU145 and PC3 was assayed for kisspeptin immunoreactivity (-IR). Kisspeptin-IR release was detectable from all three cell lines. The effect of hydroxy-flutamide, gefitinib and resveratrol on kisspeptin-IR release from these cell lines was also investigated. No effect of the drugs tested on release of kisspeptin-IR was observed. 2) Expression of KiSS-1 in human prostate tissue (n=4) was investigated using in situ hybridisation. Expression of KiSS-1 was detected in human prostate tissue. 3) Plasma kisspeptin-IR was compared in 92 patients with prostatic carcinoma and 73 male controls. Kisspeptin-IR was not detected in the plasma of either patients with prostate cancer or control patients. We have therefore shown for the first time the release of kisspeptin-IR by prostatic carcinoma cell lines. We have also shown that KiSS-1 is expressed in human prostate tissue, and that circulating levels of kisspeptin-IR are not elevated in patients with prostatic carcinoma. Further work is required to determine the role of kisspeptin in the prostate.
Gardiner JV, Bataveljic A, Patel NA, et al., 2009, Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake, Diabetes, Vol: 59, Pages: 397-406, ISSN: 0012-1797
OBJECTIVE Prokineticin 2 (PK2) is a hypothalamic neuropeptide expressed in central nervous system areas known to be involved in food intake. We therefore hypothesized that PK2 plays a role in energy homeostasis.RESEARCH DESIGN AND METHODS We investigated the effect of nutritional status on hypothalamic PK2 expression and effects of PK2 on the regulation of food intake by intracerebroventricular (ICV) injection of PK2 and anti-PK2 antibody. Subsequently, we investigated the potential mechanism of action by determining sites of neuronal activation after ICV injection of PK2, the hypothalamic site of action of PK2, and interaction between PK2 and other hypothalamic neuropeptides regulating energy homeostasis. To investigate PK2's potential as a therapeutic target, we investigated the effect of chronic administration in lean and obese mice.RESULTS Hypothalamic PK2 expression was reduced by fasting. ICV administration of PK2 to rats potently inhibited food intake, whereas anti-PK2 antibody increased food intake, suggesting that PK2 is an anorectic neuropeptide. ICV administration of PK2 increased c-fos expression in proopiomelanocortin neurons of the arcuate nucleus (ARC) of the hypothalamus. In keeping with this, PK2 administration into the ARC reduced food intake and PK2 increased the release of α-melanocyte–stimulating hormone (α-MSH) from ex vivo hypothalamic explants. In addition, ICV coadministration of the α-MSH antagonist agouti-related peptide blocked the anorexigenic effects of PK2. Chronic peripheral administration of PK2 reduced food and body weight in lean and obese mice.CONCLUSIONS This is the first report showing that PK2 has a role in appetite regulation and its anorectic effect is mediated partly via the melanocortin system.
Jayasena CN, Nijher GMK, Chaudhri OB, et al., 2009, Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 94, Pages: 4315-4323, ISSN: 0021-972X
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- Citations: 150
Patterson M, Murphy KG, Patel SR, et al., 2009, Hypothalamic Injection of Oxyntomodulin Suppresses Circulating Ghrelin-Like Immunoreactivity, ENDOCRINOLOGY, Vol: 150, Pages: 3513-3520, ISSN: 0013-7227
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- Citations: 14
Semjonous NM, Smith KL, Parkinson JRC, et al., 2009, Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance, International Journal of Obesity, Vol: 33, Pages: 775-785, ISSN: 0307-0565
Cooke JH, Patterson M, Patel SR, et al., 2009, Peripheral and Central Administration of Xenin and Neurotensin Suppress Food Intake in Rodents, OBESITY, Vol: 17, Pages: 1135-1143, ISSN: 1930-7381
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- Citations: 80
Ashby DR, Gale DP, Busbridge M, et al., 2009, Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease, KIDNEY INTERNATIONAL, Vol: 75, Pages: 976-981, ISSN: 0085-2538
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- Citations: 235
Druce MR, Minnion JS, Field BCT, et al., 2009, Investigation of Structure-Activity Relationships of Oxyntomodulin (Oxm) Using Oxm Analogs, ENDOCRINOLOGY, Vol: 150, Pages: 1712-1721, ISSN: 0013-7227
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- Citations: 72
Dhillo WS, Bewick GA, White NE, et al., 2009, The thyroid hormone derivative 3-iodothyronamine increases food intake in rodents, DIABETES OBESITY & METABOLISM, Vol: 11, Pages: 251-260, ISSN: 1462-8902
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- Citations: 39
Thompson EL, Amber V, Stamp GWH, et al., 2009, Kisspeptin-54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 156, Pages: 609-625, ISSN: 0007-1188
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- Citations: 43
Ashby D, Ford H, Wynne K, et al., 2009, Sustained appetite improvement in malnourished dialysis patients with daily subctanous ghrelin, Kidney International, Vol: 2, Pages: 199-206
Green DA, Golding JF, Aulakh M, et al., 2008, Adaptation of ventilation to 'buffeting' in vehicles., Clin Auton Res, Vol: 18, Pages: 351-351, ISSN: 0959-9851
Green DA, Golding JF, Mandip A, et al., 2008, Adaptation of ventilation to 'buffeting' in vehicles, CLINICAL AUTONOMIC RESEARCH, Vol: 18, Pages: 346-U1, ISSN: 0959-9851
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- Citations: 3
Liu Y-L, Semjonous NM, Murphy KG, et al., 2008, The effects of pancreatic polypeptide on locomotor activity and food intake in mice, INTERNATIONAL JOURNAL OF OBESITY, Vol: 32, Pages: 1712-1715, ISSN: 0307-0565
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- Citations: 16
Smith KL, Gardiner JV, Ward HL, et al., 2008, Overexpression of CART in the PVN increases food intake and weight gain in rats, OBESITY, Vol: 16, Pages: 2239-2244, ISSN: 1930-7381
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- Citations: 38
Patel SR, Murphy KG, Thompson EL, et al., 2008, Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic-pituitary-gonadal axis via gonadotropin-releasing hormone in rats, ENDOCRINOLOGY, Vol: 149, Pages: 4747-4754, ISSN: 0013-7227
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- Citations: 48
McGowan BM, Stanley SA, Donovan J, et al., 2008, Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 295, Pages: E278-E286, ISSN: 0193-1849
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- Citations: 64
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