Imperial College London
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ProfessorKevinMurphy

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 3313 2156k.g.murphy Website

 
 
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Location

 

6N2DCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

179 results found

Gardiner JV, Kong WM, Ward H, Murphy KG, Dhillo WS, Bloom SRet al., 2005, AAV mediated expression of anti-sense neuropeptide Y cRNA in the arcuate nucleus of rats results in decreased weight gain and food intake, Biochemical and Biophysical research Communications, Vol: 327, Pages: 1088-1093

Journal article

Thompson EL, Murphy KG, Todd JF, Martin NM, Small CJ, Ghatei MA, Bloom SRet al., 2004, Chronic administration of NMU into the paraventricular nucleus stimulates the HPA axis but does not influence food intake or body weight, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 323, Pages: 65-71, ISSN: 0006-291X

Journal article

Thompson EL, Patterson M, Murphy KG, Smith KL, Dhillo WS, Todd JF, Ghatei MA, Bloom SRet al., 2004, Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 16, Pages: 850-858, ISSN: 0953-8194

Journal article

Murphy KG, Bloom SR, 2004, Gut hormones in the control of appetite, EXPERIMENTAL PHYSIOLOGY, Vol: 89, Pages: 507-516, ISSN: 0958-0670

Journal article

Stanley SA, Murphy KG, Bewick GA, Kong WM, Opacka-Juffry J, Gardiner JV, Ghatei MA, Small CJ, Bloom SRet al., 2004, Regulation of rat pituitary cocaine- and amphetamine-regulated transcript (CART) by CRH and glucocorticoids, American Journal of Physiology Endocrinology and Metabolism, Vol: 287, Pages: E583-E590

Journal article

Abbott CR, Kennedy AR, Wren AM, Rossi M, Murphy KG, Seal LJ, Todd JF, Ghatei MA, Small CJ, Bloom SRet al., 2003, Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone, ENDOCRINOLOGY, Vol: 144, Pages: 3943-3949, ISSN: 0013-7227

Journal article

Dhillo WS, Small CJ, Jethwa PH, Russell SH, Gardiner JV, Bewick GA, Seth A, Murphy KG, Ghatei MA, Bloom SRet al., 2003, Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis, ENDOCRINOLOGY, Vol: 144, Pages: 1420-1425, ISSN: 0013-7227

Journal article

Kong WM, Stanley S, Gardiner J, Abbott C, Murphy K, Seth A, Connoley I, Ghatei M, Stephens D, Bloom Set al., 2003, A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol: 17, Pages: 1688-1690

We have recently shown that injection of the hypothalamic peptide cocaine and amphetamine regulated transcript (CART) into discrete hypothalamic nuclei stimulates food intake. This stimulation was particularly marked in the arcuate nucleus. Here we show that twice daily intra-arcuate injection of 0.2 nmole CART peptide for 7 days was associated with a 60% higher daytime food intake, an 85% higher thermogenic response to the beta3 agonist BRL 35135, and a 60% increase in brown adipose tissue UCP-1 mRNA. In a separate study, using stereotactically targeted gene transfer, a CART transgene was delivered by using polyethylenimine to the arcuate nucleus of adult rats. Food intake was increased significantly during ad libitum feeding and following periods of food withdrawal and food restriction in CART over-expressing animals. CART over-expressing animals lost 12% more weight than controls following a 24-h fast. Brown adipose tissue uncoupling protein-1 (UCP-1) mRNA levels (collected Day 25) were 80% higher in CART over-expressing animals. Finally, by using quantitative in situ hybridization, we found that chronic cold exposure (20 days at 4oC) increased arcuate nucleus CART mRNA by 124%. Together with the orexigenic and thermogenic effects of CART, this finding suggests a role for arcuate nucleus CART in cold adaptation.

Journal article

Ward H, Gardiner J, Kong WM, Murphy K, Bloom Set al., 2003, Distribution of fluorescence following injection of recombinant adeno-associated virus encoding green fluorescent protein into the paraventricular nucleus, Neuroendocrinology, Vol: 77, Pages: 100-104

Journal article

Seth A, Stanley S, Dhillo W, Murphy K, Ghatei M, Bloom Set al., 2003, Effects of galanin-like Peptide on food intake and the hypothalamo-pituitary-thyroid axis, Neuroendocrinology, Vol: 77, Pages: 125-131

Journal article

Kong WM, Stanley S, Gardiner J, Abbott C, Murphy K, Seth A, Connoley I, Ghatei M, Stephens D, Bloom Set al., 2003, A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation., FASEB J, Vol: 15, Pages: 1688-1690

Journal article

Wren AM, Small CJ, Abbott CR, Jethwa PH, Kennedy AR, Murphy KG, Stanley SA, Zollner AN, Ghatei MA, Bloom SRet al., 2002, Hypothalamic actions of neuromedin U, ENDOCRINOLOGY, Vol: 143, Pages: 4227-4234, ISSN: 0013-7227

Journal article

Dhillo WS, Small CJ, Stanley SA, Jethwa PH, Seal LJ, Murphy KG, Ghatei MA, Bloom SRet al., 2002, Hypothalamic interactions between neuropeptide Y, agouti-related protein, cocaine- and amphetamine-regulated transcript and alpha-melanocyte-stimulating hormone <i>in vitro</i> in male rats, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 14, Pages: 725-730, ISSN: 0953-8194

Journal article

Dhillo WS, Small CJ, Seal LJ, Kim MS, Stanley SA, Murphy KG, Ghatei MA, Bloom SRet al., 2002, The hypothalamic melanocortin system stimulates the hypothalamo-pituitary-adrenal axis in vitro and in vivo in male rats, NEUROENDOCRINOLOGY, Vol: 75, Pages: 209-216, ISSN: 0028-3835

Journal article

Taheri S, Murphy K, Cohen M, Sujkovic E, Kennedy A, Dhillo W, Dakin C, Sajedi A, Ghatei M, Bloom Set al., 2002, The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 291, Pages: 1208-1212, ISSN: 0006-291X

Journal article

Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SRet al., 2001, Ghrelin enhances appetite and increases food intake in humans, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 86, Pages: 5992-5995, ISSN: 0021-972X

Journal article

Russell SH, Small CJ, Kennedy AR, Stanley SA, Seth A, Murphy KG, Taheri S, Ghatei MA, Bloom SRet al., 2001, Orexin A interactions in the hypothalamo-pituitary gonadal axis, ENDOCRINOLOGY, Vol: 142, Pages: 5294-5302, ISSN: 0013-7227

Journal article

Ward HL, Small CJ, Murphy KG, Kennedy AR, Ghatei MA, Bloom SRet al., 2001, The actions of tuberoinfundibular peptide on the hypothalamo-pituitary axes, ENDOCRINOLOGY, Vol: 142, Pages: 3451-3456, ISSN: 0013-7227

Journal article

Abbott CR, Rossi M, Wren AM, Murphy KG, Kennedy AR, Stanley SA, Zollner AN, Morgan DGA, Morgan I, Ghatei MA, Small CJ, Bloom SRet al., 2001, Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei, ENDOCRINOLOGY, Vol: 142, Pages: 3457-3463, ISSN: 0013-7227

Journal article

Sunter D, Morgan I, Edwards CMB, Dakin CL, Murphy KG, Gardiner J, Taheri S, Rayes E, Bloom SRet al., 2001, Orexins: effects on behavior and localisation of orexin receptor 2 messenger ribonucleic acid in the rat brainstem, BRAIN RESEARCH, Vol: 907, Pages: 27-34, ISSN: 0006-8993

Journal article

Taheri S, Gardiner J, Hafizi S, Murphy K, Dakin C, Seal L, Small C, Ghatei M, Bloom Set al., 2001, Orexin A immunoreactivity and prepro-orexin mRNA in the brain of Zucker and WKY rats, NEUROREPORT, Vol: 12, Pages: 459-464, ISSN: 0959-4965

Journal article

Stanley SA, Small CJ, Murphy KG, Rayes E, Abbott CR, Seal LJ, Morgan DGA, Sunter D, Dakin CL, Kim MS, Hunter R, Kuhar M, Ghatei MA, Bloom SRet al., 2001, Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats, BRAIN RESEARCH, Vol: 893, Pages: 186-194, ISSN: 0006-8993

Journal article

Small CJ, Kim MS, Stanley SA, Mitchell JRD, Murphy K, Morgen DGA, Ghatei MA, Bloom SRet al., 2001, Effects of chronic central nervous system administration of agouti-related protein in pair-fed animals, DIABETES, Vol: 50, Pages: 248-254, ISSN: 0012-1797

Journal article

Russell SH, Kim MS, Small CJ, Abbott CR, Morgan DGA, Taheri S, Murphy KG, Todd JF, Ghatei MA, Bloom SRet al., 2000, Central administration of orexin A suppresses basal and domperidone stimulated plasma prolactin, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 12, Pages: 1213-1218, ISSN: 0953-8194

Journal article

Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DGA, Ghatei MA, Bloom SRet al., 2000, The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion., ENDOCRINOLOGY, Vol: 141, Pages: 4325-4328, ISSN: 0013-7227

Journal article

Murphy KG, Abbott CR, Mahmoudi M, Hunter R, Gardiner JV, Rossi M, Stanley SA, Ghatei MA, Kuhar MJ, Bloom SRet al., 2000, Quantification and synthesis of cocaine- and amphetamine-regulated transcript peptide (79-102)-like immunoreactivity and mRNA in rat tissues, JOURNAL OF ENDOCRINOLOGY, Vol: 166, Pages: 659-668, ISSN: 0022-0795

Journal article

Edwards CMB, Abbott CR, Sunter D, Kim MS, Dakin CL, Murphy KG, Abusnana S, Taheri S, Rossi M, Bloom SRet al., 2000, Cocaine- and amphetamine-regulated transcript, glucagon-like peptide-1 and corticotrophin releasing factor inhibit feeding via agouti-related protein independent pathways in the rat, BRAIN RESEARCH, Vol: 866, Pages: 128-134, ISSN: 0006-8993

Journal article

Satoh F, Smith DM, Gardiner JV, Mahmoodi M, Murphy KG, Ghatei MA, Bloom SRet al., 2000, Characterization and distribution of prolactin releasing peptide (PrRP) binding sites in the rat - evidence for a novel binding site subtype in cardiac and skeletal muscle, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 129, Pages: 1787-1793, ISSN: 0007-1188

Journal article

Edwards CMB, Abusnana S, Sunter D, Murphy KG, Ghatel MA, Bloom SRet al., 1999, The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin, JOURNAL OF ENDOCRINOLOGY, Vol: 160, Pages: R7-R12, ISSN: 0022-0795

Journal article

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