Imperial College London
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ProfessorKevinMurphy

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology & Metabolism
 
 
 
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Contact

 

+44 (0)20 3313 2156k.g.murphy Website

 
 
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Location

 

6N2DCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Alamshah:2016:10.1111/dom.12644,
author = {Alamshah, A and McGavigan, AK and Spreckley, E and Kinsey-Jones, JS and Amin, A and Tough, IR and O'Hara, HC and Moolla, A and Banks, K and France, R and Hyberg, G and Norton, M and Cheong, W and Lehmann, A and Bloom, SR and Cox, HM and Murphy, KG},
doi = {10.1111/dom.12644},
journal = {Diabetes Obesity & Metabolism},
pages = {508--518},
title = {L-Arginine promotes gut hormone release and reduces food intake in rodents},
url = {http://dx.doi.org/10.1111/dom.12644},
volume = {18},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AimsThe amino acids generated by protein digestion may play a role in the weight loss driven by high protein diets. We investigated the anorectic effect of L-arginine (L-Arg) in rodents.Materials and MethodsWe investigated the effect of L-Arg on food intake, and the role of the anorectic gut hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), the G protein-coupled receptor family C group 6 member A (GPRC6A) and the vagus nerve in mediating these effects in rodents.ResultsOral gavage of L-Arg reduced food intake in rodents, and chronically reduced cumulative food intake in diet-induced obese mice. Lack of the GPRC6A in mice or subdiaphragmatic vagal deafferentation in rats did not influence these anorectic effects. L-Arg stimulated GLP-1 and PYY release in vitro and in vivo. Pharmacological blockade of GLP-1 and PYY receptors did not influence the anorectic effect of L-Arg. L-Arg-mediated PYY release modulated net ion transport across the gut mucosa. Intracerebroventricular (ICV) and intraperitoneal (IP) administration of L-Arg suppressed food intake in rats.ConclusionsL-Arg reduced food intake and stimulated gut hormone release in rodents. The anorectic effect of L-Arg is unlikely to be mediated by GLP-1 and PYY, does not require GPRC6A signalling and is not mediated via the vagus. ICV and IP administration of L-Arg suppressed food intake in rats, suggesting that L-Arg may act upon the brain to influence food intake. Further work is required to determine the mechanisms by which L-Arg suppresses food intake and its utility in the treatment of obesity.
AU  - Alamshah,A
AU  - McGavigan,AK
AU  - Spreckley,E
AU  - Kinsey-Jones,JS
AU  - Amin,A
AU  - Tough,IR
AU  - O'Hara,HC
AU  - Moolla,A
AU  - Banks,K
AU  - France,R
AU  - Hyberg,G
AU  - Norton,M
AU  - Cheong,W
AU  - Lehmann,A
AU  - Bloom,SR
AU  - Cox,HM
AU  - Murphy,KG
DO  - 10.1111/dom.12644
EP  - 518
PY  - 2016///
SN  - 1463-1326
SP  - 508
TI  - L-Arginine promotes gut hormone release and reduces food intake in rodents
T2  - Diabetes Obesity & Metabolism
UR  - http://dx.doi.org/10.1111/dom.12644
UR  - http://hdl.handle.net/10044/1/29444
VL  - 18
ER  -
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