Imperial College London
Alternate

Prof Klaus Hellgardt

Faculty of Engineering, Department of Chemical Engineering

Professor of Chemical Engineering
 
 
 
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Contact

 

+44 (0)20 7594 5577k.hellgardt

 
 
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Location

 

417AACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wang:2021:10.1039/d1re00343g,
author = {Wang, S and Panayides, J-L and Riley, D and Tighe, CJ and Hellgardt, K and Hii, KKM and Miller, PW},
doi = {10.1039/d1re00343g},
journal = {Reaction Chemistry and Engineering},
pages = {2018--2023},
title = {Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow},
url = {http://dx.doi.org/10.1039/d1re00343g},
volume = {6},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The functionalisation of imidazoles is a necessary step in the formation of many active pharmaceutical intermediates. Herein, we report a flow chemistry approach for the rapid and efficient formation of 2-lithio-1-(triphenylmethyl)imidazole at ambient temperature and its reaction with a range of electrophiles, achieving modest to high yields (40–94%) in short reaction times (<1 min). The method is amenable to the scale-up of this highly reactive lithio-imidazole intermediate.
AU  - Wang,S
AU  - Panayides,J-L
AU  - Riley,D
AU  - Tighe,CJ
AU  - Hellgardt,K
AU  - Hii,KKM
AU  - Miller,PW
DO  - 10.1039/d1re00343g
EP  - 2023
PY  - 2021///
SN  - 2058-9883
SP  - 2018
TI  - Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow
T2  - Reaction Chemistry and Engineering
UR  - http://dx.doi.org/10.1039/d1re00343g
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000700913300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.rsc.org/en/content/articlelanding/2021/RE/D1RE00343G
UR  - http://hdl.handle.net/10044/1/91953
VL  - 6
ER  -
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