Imperial College London
Alternate

Professor Kazuhiro Ito

Faculty of Medicine, National Heart & Lung Institute

Principal Research Fellow in Respiratory Molecular Pharmacol
 
 
 
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Contact

 

+44 (0)20 7594 0953k.ito Website

 
 
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Location

 

412Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

268 results found

To Y, Ito K, Kizawa Y, Failla M, Ito M, Kusama T, Elliott WM, Hogg JC, Adcock IM, Barnes PJet al., 2010, Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 182, Pages: 897-904, ISSN: 1073-449X

Journal article

Kankaanranta H, Janka-Junttila M, Ilmarinen-Salo P, Ito K, Jalonen U, Ito M, Adcock IM, Moilanen E, Zhang Xet al., 2010, Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils, Journal of Inflammation, Vol: 7, ISSN: 1078-7852

Journal article

Brindicci C, Kharitonov SA, Ito M, Elliott MW, Hogg JC, Barnes PJ, Ito Ket al., 2010, Nitric Oxide Synthase Isoenzyme Expression and Activity in Peripheral Lung Tissue of Patients with Chronic Obstructive Pulmonary Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, Pages: 21-30, ISSN: 1073-449X

Journal article

Kizawa Y, Eto S, Ueda K, Ito K, Barnes PJ, Kusama Tet al., 2010, Possible involvement of TLR3 pathway on corticosteroid refractory airway inflammation in mice, 83rd Annual Meeting of the Japanese-Pharmacological-Society, Publisher: JAPANESE PHARMACOLOGICAL SOC, Pages: 205P-205P, ISSN: 1347-8613

Conference paper

Kizawa Y, Watanabe Y, Eto S, Ueda K, Rapeport G, Strong P, Ito K, Barnes PJ, Kusama Tet al., 2010, Involvement Of P38MAPK Gamma On Corticosteroid Refractory Airway Inflammation Induced By Tobacco Smoke In Mice, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, ISSN: 1073-449X

Journal article

Caramori G, Ito K, Casolari P, Contoli M, Papi A, Adcock IMet al., 2010, Targeting Th2 Cells in Asthmatic Airways, ALLERGY FRONTIERS: FUTURE PERSPECTIVES, VOL 6, Editors: Pawankar, Holgate, Rosenwasser, Publisher: SPRINGER-VERLAG BERLIN, Pages: 103-147, ISBN: 978-4-431-99364-3

Book chapter

Charron CE, Chou P-C, Coutts DJC, Kumar V, To M, Akashi K, Pinhu L, Griffiths M, Adcock IM, Barnes PJ, Ito Ket al., 2009, Hypoxia-inducible Factor 1α Induces Corticosteroid-insensitive Inflammation via Reduction of Histone Deacetylase-2 Transcription, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 284, Pages: 36047-36054

Journal article

Wort SJ, Ito M, Chou P-C, Mc Master SK, Badiger R, Jazrawi E, de Souza P, Evans TW, Mitchell JA, Pinhu L, Ito K, Adcock IMet al., 2009, Synergistic Induction of Endothelin-1 by Tumor Necrosis Factor α and Interferon γ Is due to Enhanced NF-κB Binding and Histone Acetylation at Specific κB Sites, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 284, Pages: 24297-24305

Journal article

Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Kharitonov S, Goto H, Bemis JE, Elliott P, Barnes PJ, Ito Ket al., 2009, A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9, FASEB JOURNAL, Vol: 23, Pages: 2810-2819, ISSN: 0892-6638

Journal article

Ito K, Mercado N, 2009, Therapeutic targets for new therapy for corticosteroid refractory asthma, EXPERT OPINION ON THERAPEUTIC TARGETS, Vol: 13, Pages: 1053-1067, ISSN: 1472-8222

Journal article

Caramori G, Casolari P, Di Gregorio C, Saetta M, Baraldo S, Boschetto P, Ito K, Fabbri LM, Barnes PJ, Adcock IM, Cavallesco G, Chung KF, Papi Aet al., 2009, MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients, HISTOPATHOLOGY, Vol: 55, Pages: 321-331, ISSN: 0309-0167

Journal article

Osoata GO, Yamamura S, Ito M, Vuppusetty C, Adcock IM, Barnes PJ, Ito Ket al., 2009, Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 384, Pages: 366-371, ISSN: 0006-291X

Journal article

Ho S-C, Lee K-Y, Chan Y-F, Kuo L-W, Ito K, Adcock IM, Chen B-C, Sheu J-R, Lin C-H, Kuo H-Pet al., 2009, Neutrophil Elastase Represses IL-8/CXCL8 Synthesis in Human Airway Smooth Muscle Cells through Induction of NF-κB Repressing Factor, JOURNAL OF IMMUNOLOGY, Vol: 183, Pages: 411-420, ISSN: 0022-1767

Journal article

Spears M, Donnelly I, Jolly L, Brannigan M, Ito K, McSharry C, Lafferty J, Chaudhuri R, Braganza G, Bareille P, Sweeney L, Adcock IM, Barnes PJ, Wood S, Thomson NCet al., 2009, Bronchodilatory Effect of the PPAR-γ Agonist Rosiglitazone in Smokers With Asthma, CLINICAL PHARMACOLOGY & THERAPEUTICS, Vol: 86, Pages: 49-53, ISSN: 0009-9236

Journal article

Osoata GO, Hanazawa T, Brindicci C, Ito M, Barnes PJ, Kharitonov S, Ito Ket al., 2009, Peroxynitrite Elevation in Exhaled Breath Condensate of COPD and Its Inhibition by Fudosteine, CHEST, Vol: 135, Pages: 1513-1520, ISSN: 0012-3692

Journal article

Maneechotesuwan K, Yao X, Ito K, Jazrawi E, Usmani OS, Adcock IM, Barnes PJet al., 2009, Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease, PLOS MEDICINE, Vol: 6, ISSN: 1549-1676

Journal article

Cosio BG, Iglesias A, Rios A, Noguera A, Sala E, Ito K, Barnes PJ, Agusti Aet al., 2009, Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of COPD, THORAX, Vol: 64, Pages: 424-429, ISSN: 0040-6376

Journal article

Spears M, Donnelly I, Jolly L, Brannigan M, Ito K, McSharry C, Lafferty J, Chaudhuri R, Braganza G, Adcock IM, Barnes PJ, Wood S, Thomson NCet al., 2009, Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study, EUROPEAN RESPIRATORY JOURNAL, Vol: 33, Pages: 1010-1017, ISSN: 0903-1936

Journal article

Marwick JA, Caramori G, Stevenson CS, Casolari P, Jazrawi E, Barnes PJ, Ito K, Adcock IM, Kirkham PA, Papi Aet al., 2009, Inhibition of PI3Kδ Restores Glucocorticoid Function in Smoking-induced Airway Inflammation in Mice, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, Pages: 542-548, ISSN: 1073-449X

Journal article

Ito K, Ishibashi K-I, Tomiyama T, Umeda T, Yamamoto K-I, Kitajima E, Idomoto T, Nagatomo T, Mori Het al., 2009, Oligomeric Amyloid β-Protein as a Therapeutic Target in Alzheimer's Disease: Its Significance Based on its Distinct Localization and the Occurrence of a Familial Variant Form, 10th International Hong Kong/Springfield Pan-Asian Symposium on Advances in Alzheimer Therapy, Publisher: BENTHAM SCIENCE PUBL LTD, Pages: 132-136, ISSN: 1567-2050

Conference paper

Caramori G, Oates T, Nicholson AG, Casolari P, Ito K, Barnes PJ, Papi A, Adcock IM, Chung KFet al., 2009, Activation of NF-κB transcription factor in asthma death, HISTOPATHOLOGY, Vol: 54, Pages: 507-509, ISSN: 0309-0167

Journal article

Brindicci C, Ito K, Torre O, Barnes PJ, Kharitonov SAet al., 2009, Effects of Aminoguanidine, an Inhibitor of Inducible Nitric Oxide Synthase, on Nitric Oxide Production and Its Metabolites in Healthy Control Subjects, Healthy Smokers, and COPD Patients, CHEST, Vol: 135, Pages: 353-367, ISSN: 0012-3692

Journal article

Ito K, Barnes PJ, 2009, COPD as a disease of accelerated lung aging, REVISTA PORTUGUESA DE PNEUMOLOGIA, Vol: 15, Pages: 743-746, ISSN: 0873-2159

Journal article

Ito K, Barnes PJ, 2009, COPD as a Disease of Accelerated Lung Aging, CHEST, Vol: 135, Pages: 173-180, ISSN: 0012-3692

Journal article

Kizawa Y, Watanabe Y, Eto S, Kimura G, Saito R, Ito K, Barnes PJ, Kusama Tet al., 2009, PI3kinase signalling is more important than p38MAPkinase signalling for steroid-resistant airway inflammation in a cigarette smoking murine model, 82nd Annual Meeting of the Japanese-Pharmacological-Society, Publisher: JAPANESE PHARMACOLOGICAL SOC, Pages: 239P-239P, ISSN: 1347-8613

Conference paper

Rossios C, Barnes PJ, Johnson M, Ito Ket al., 2009, Fluticasone Furoate, a Novel Ultra-Long Acting Corticosteroid, Has a Prolonged Inhibitory Effect on H<sub>2</sub>O<sub>2</sub>-Induced Phosphorylation of p38 MAP Kinase Compared to That of Fluticasone Propionate., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X

Journal article

Essilfie-Quaye S, Barnes PJ, Ito K, 2009, Glucocorticoid Receptor Acetylation in Patients with COPD., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X

Journal article

Kharitonov SA, Ito K, 2009, Nitric Oxide, ASTHMA AND COPD: BASIC MECHANISMS AND CLINICAL MANAGEMENT, 2ND EDITION, Editors: Barnes, Drazen, Rennard, Thomson, Publisher: ELSEVIER ACADEMIC PRESS INC, Pages: 363-372, ISBN: 978-0-12-374001-4

Book chapter

Marwick JA, Wallis G, Meja K, Kuster B, Bouwmeester T, Chakravarty P, Fletcher D, Whittaker PA, Barnes PJ, Ito K, Adcock IM, Kirkham PAet al., 2008, Oxidative stress modulates theophylline effects on steroid responsiveness, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 377, Pages: 797-802, ISSN: 0006-291X

Journal article

Ito K, Herbert C, Siegle JS, Vuppusetty C, Hansbro N, Thomas PS, Foster PS, Barnes PJ, Kumar RKet al., 2008, Steroid-Resistant Neutrophilic Inflammation in a Mouse Model of an Acute Exacerbation of Asthma, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 39, Pages: 543-550, ISSN: 1044-1549

Journal article

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