My research interests focus on deciphering the functional aspects G protein-coupled receptor biology, particularly GPCR di/oligomerisation, in reproductive systems. Using super resolution imaging, we have probed the molecular landscape of gonadtrophin receptor associations, coupled to functional second messanger assays to link the di/oligomeric status of receptors to the functional output. We are looking both at homo- and heter- dimerisation of gonadtrophin receptors, and how receptor-receptor associations can provide a way of fine-tuning the signalling output of a receptor subtype to mediate the physiological requirements of key reproductive events such as ovulation.
Jonas KC, Hanyaloglu AC, 2017, Impact of G protein-coupled receptor heteromers in endocrine systems, Molecular and Cellular Endocrinology, Vol:449, ISSN:0303-7207, Pages:21-27
et al., 2015, Single molecule analysis of functionally asymmetric G protein-coupled receptor (GPCR) oligomers reveals diverse spatial and structural assemblies, Journal of Biological Chemistry, Vol:290, ISSN:1083-351X, Pages:3875-3892
et al., 2014, Mouse models of altered gonadotrophin action: insight into male reproductive disorders, Reproduction, Vol:148, ISSN:1470-1626, Pages:R63-R70
et al., 2014, Single Molecule Analysis of GPCR Transactivation Via PD-PALM Reveals Oligomeric Complexes That Regulate Signal Sensitivity, Endocrine Reviews, Vol:35, ISSN:0163-769X