Imperial College London
Alternate

Dr Kim C Jonas

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2173k.jonas

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jonas:2017:10.1016/j.mce.2017.01.030,
author = {Jonas, KC and Hanyaloglu, AC},
doi = {10.1016/j.mce.2017.01.030},
journal = {Molecular and Cellular Endocrinology},
pages = {21--27},
title = {Impact of G protein-coupled receptor heteromers in endocrine systems},
url = {http://dx.doi.org/10.1016/j.mce.2017.01.030},
volume = {449},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The fine-tuning of endocrine homeostasis is regulated by dynamic receptor mediated processes. Thesuperfamily of G protein-coupled receptors (GPCRs) have diverse roles in the modulation of all endocrineaxes, thus understanding the mechanisms underpinning their functionality is paramount for treatmentof endocrinopathies. Evidence over the last 20 years has highlighted homo and heteromerization as a keymode of mediating GPCR functional diversity. This review will discuss the concept of GPCR heteromerizationand its relevance to endocrine function, detailing in vitro and in vivo evidence, and exploringcurrent and potential pharmacological strategies for specific targeting of GPCR heteromers in endocrineheath and disease.
AU  - Jonas,KC
AU  - Hanyaloglu,AC
DO  - 10.1016/j.mce.2017.01.030
EP  - 27
PY  - 2017///
SN  - 0303-7207
SP  - 21
TI  - Impact of G protein-coupled receptor heteromers in endocrine systems
T2  - Molecular and Cellular Endocrinology
UR  - http://dx.doi.org/10.1016/j.mce.2017.01.030
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000402944900004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/49721
VL  - 449
ER  -
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