Imperial College London
Alternate

ProfessorKathMaitland

Faculty of Medicine, Department of Surgery & Cancer

Professor of Tropical Paediatric Infectious Disease
 
 
 
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Contact

 

k.maitland CV

 
 
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Location

 

Based full-time at KEMRI/Wellcome Programme, KenyaQueen Elizabeth and Queen Mary HospitalSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Uyoga:2019:10.1016/S2214-109X(19)30328-6,
author = {Uyoga, S and Macharia, AW and Mochamah, G and Ndila, CM and Nyutu, G and Makale, J and Tendwa, M and Nyatichi, E and Ojal, J and Otiende, M and Shebe, M and Awuondo, KO and Mturi, N and Peshu, N and Tsofa, B and Maitland, K and Scott, JAG and Williams, TN},
doi = {10.1016/S2214-109X(19)30328-6},
journal = {The Lancet Global Health},
pages = {e1458--e1466},
title = {The epidemiology of sickle cell disease in children recruited in infancy in Kilifi, Kenya: a prospective cohort study.},
url = {http://dx.doi.org/10.1016/S2214-109X(19)30328-6},
volume = {7},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Sickle cell disease is the most common severe monogenic disorder in humans. In Africa, 50-90% of children born with sickle cell disease die before they reach their fifth birthday. In this study, we aimed to describe the comparative incidence of specific clinical outcomes among children aged between birth and 5 years with and without sickle cell disease, who were resident within the Kilifi area of Kenya. METHODS: This prospective cohort study was done on members of the Kilifi Genetic Birth Cohort Study (KGBCS) on the Indian Ocean coast of Kenya. Recruitment to the study was facilitated through the Kilifi Health and Demographic Surveillance System (KHDSS), which covers a resident population of 260000 people, and was undertaken between Jan 1, 2006, and April 30, 2011. All children who were born within the KHDSS area and who were aged 3-12 months during the recruitment period were eligible for inclusion. Participants were tested for sickle cell disease and followed up for survival status and disease-specific admission to Kilifi County Hospital by passive surveillance until their fifth birthday. Children with sickle cell disease were offered confirmatory testing and care at a dedicated outpatient clinic. FINDINGS: 15737 infants were recruited successfully to the KGBCS, and 128 (0·8%) of these infants had sickle cell disease, of whom 70 (54·7%) enrolled at the outpatient clinic within 12 months of recruitment. Mortality was higher in children with sickle cell disease (58 per 1000 person-years of observation, 95% CI 40-86) than in those without sickle cell disease (2·4 per 1000 person-years of observation, 2·0-2·8; adjusted incidence rate ratio [IRR] 23·1, 95% CI 15·1-35·3). Among children with sickle cell disease, mortality was lower in those who enrolled at the clinic (adjusted IRR 0·26, 95% CI 0·11-0·62) and in those with higher levels of haemoglobin F (HbF; adjusted IRR 0·
AU  - Uyoga,S
AU  - Macharia,AW
AU  - Mochamah,G
AU  - Ndila,CM
AU  - Nyutu,G
AU  - Makale,J
AU  - Tendwa,M
AU  - Nyatichi,E
AU  - Ojal,J
AU  - Otiende,M
AU  - Shebe,M
AU  - Awuondo,KO
AU  - Mturi,N
AU  - Peshu,N
AU  - Tsofa,B
AU  - Maitland,K
AU  - Scott,JAG
AU  - Williams,TN
DO  - 10.1016/S2214-109X(19)30328-6
EP  - 1466
PY  - 2019///
SN  - 2214-109X
SP  - 1458
TI  - The epidemiology of sickle cell disease in children recruited in infancy in Kilifi, Kenya: a prospective cohort study.
T2  - The Lancet Global Health
UR  - http://dx.doi.org/10.1016/S2214-109X(19)30328-6
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31451441
UR  - https://www.sciencedirect.com/science/article/pii/S2214109X19303286?via%3Dihub
UR  - http://hdl.handle.net/10044/1/73224
VL  - 7
ER  -
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