Imperial College London
Alternate

ProfessorKathMaitland

Faculty of Medicine, Department of Surgery & Cancer

Professor of Tropical Paediatric Infectious Disease
 
 
 
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Contact

 

k.maitland CV

 
 
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Location

 

Based full-time at KEMRI/Wellcome Programme, KenyaQueen Elizabeth and Queen Mary HospitalSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Maitland:2021:10.1111/bjh.17429,
author = {Maitland, K and Kiguli, S and Olupot-Olupot, P and Opoka, RO and Chimalizeni, Y and Alaroker, F and Uyoga, S and Kyeyune, Byabazaire D and Mbaya, B and Bates, I and Williams, TN and Mbanya, D and Munube, D and Molyneux, EM and South, A and Walker, AS and Gibb, DM and George, EM},
doi = {10.1111/bjh.17429},
journal = {British Journal of Haematology},
pages = {1247--1259},
title = {Transfusion management of severe anaemia in African children: a consensus algorithm},
url = {http://dx.doi.org/10.1111/bjh.17429},
volume = {193},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The phase III Transfusion and Treatment of severe anaemia in African Children Trial(TRACT) found that conservative management of uncomplicated severe anaemia (haemoglobin(Hb)4-6g/dl) was safe and that transfusion volume(20 versus30 mls/kg whole blood equivalent)for children with severe anaemia (Hb<6g/dl) had strong but opposing effects on mortality, depending on fever status (>37.5oC). In 2020 a stakeholder meeting of paediatric and blood transfusion groups from Africa reviewed  the  results  and  additional  analyses. Among  all  children  (3196)  receiving  an  initial transfusion,  there  was  no  evidence  that nutritional  status, presence  of  shock, malaria parasite burden, or   sickle cell disease status influenced outcomes, or modified the interaction with fever status on volume required.  Fever status at the time of ordering blood was a reliable determinant of  volume  required  for  optimal  outcome.    Elevated  heart  and  respiratory  rates  normalised irrespective of transfusion volume and without diuretics. By consensus, a transfusion management algorithm  was  developed,  incorporating  3  additional  measurements  of  Hb  post-admission, alongside  clinical  monitoring.    The proposed  algorithm  should  help  clinicians  safely  implement findings from TRACT. Further research should assess its implementation in routine clinical practice
AU  - Maitland,K
AU  - Kiguli,S
AU  - Olupot-Olupot,P
AU  - Opoka,RO
AU  - Chimalizeni,Y
AU  - Alaroker,F
AU  - Uyoga,S
AU  - Kyeyune,Byabazaire D
AU  - Mbaya,B
AU  - Bates,I
AU  - Williams,TN
AU  - Mbanya,D
AU  - Munube,D
AU  - Molyneux,EM
AU  - South,A
AU  - Walker,AS
AU  - Gibb,DM
AU  - George,EM
DO  - 10.1111/bjh.17429
EP  - 1259
PY  - 2021///
SN  - 0007-1048
SP  - 1247
TI  - Transfusion management of severe anaemia in African children: a consensus algorithm
T2  - British Journal of Haematology
UR  - http://dx.doi.org/10.1111/bjh.17429
UR  - https://onlinelibrary.wiley.com/doi/10.1111/bjh.17429
UR  - http://hdl.handle.net/10044/1/88206
VL  - 193
ER  -
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