Imperial College London
Alternate

ProfessorKathMaitland

Faculty of Medicine, Department of Surgery & Cancer

Professor of Tropical Paediatric Infectious Disease
 
 
 
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Contact

 

k.maitland CV

 
 
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Location

 

Based full-time at KEMRI/Wellcome Programme, KenyaQueen Elizabeth and Queen Mary HospitalSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kiguli:2021:10.12688/wellcomeopenres.17123.2,
author = {Kiguli, S and Olopot-Olupot, P and Alaroker, F and Engoru, C and Opoka, RO and Tagoola, A and Hamaluba, M and Mnjalla, H and Mpoya, A and Mogaka, C and Nalwanga, D and Nabawanuka, E and Nokes, J and Nyaigoti, C and Briend, A and van, Woensel JBM and Grieve, R and Sadique, Z and Williams, TN and Thomas, K and Harrison, DA and Rowan, K and Maitland, K},
doi = {10.12688/wellcomeopenres.17123.2},
journal = {Wellcome Open Res},
pages = {221--221},
title = {Children's Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial.},
url = {http://dx.doi.org/10.12688/wellcomeopenres.17123.2},
volume = {6},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: To prevent poor long-term outcomes (deaths and readmissions) the integrated global action plan for pneumonia and diarrhoea recommends under the 'Treat' element of Protect, Prevent and Treat interventions the importance of continued feeding but gives no specific recommendations for nutritional support. Early nutritional support has been practiced in a wide variety of critically ill patients to provide vital cell substrates, antioxidants, vitamins, and minerals essential for normal cell function and decreasing hypermetabolism. We hypothesise that the excess post-discharge mortality associated with pneumonia may relate to the catabolic response and muscle wasting induced by severe infection and inadequacy of the diet to aid recovery. We suggest that providing additional energy-rich, protein, fat and micronutrient ready-to-use therapeutic feeds (RUTF) to help meet additional nutritional requirements may improve outcome. Methods: COAST-Nutrition is an open, multicentre, Phase II randomised controlled trial in children aged 6 months to 12 years hospitalised with suspected severe pneumonia (and hypoxaemia, SpO 2 <92%) to establish whether supplementary feeds with RUTF given in addition to usual diet for 56-days (experimental) improves outcomes at 90-days compared to usual diet alone (control). Primary endpoint is change in mid-upper arm circumference (MUAC) at 90 days and/or as a composite with 90-day mortality. Secondary outcomes include anthropometric status, mortality, readmission at days 28 and 180. The trial will be conducted in four sites in two countries (Uganda and Kenya) enrolling 840 children followed up to 180 days. Ancillary studies include cost-economic analysis, molecular characterisation of bacterial and viral pathogens, evaluation of putative biomarkers of pneumonia, assessment of muscle and fat mass and host genetic studies.   Discussion: This study is the first step in providing an option for nutritional support following severe p
AU  - Kiguli,S
AU  - Olopot-Olupot,P
AU  - Alaroker,F
AU  - Engoru,C
AU  - Opoka,RO
AU  - Tagoola,A
AU  - Hamaluba,M
AU  - Mnjalla,H
AU  - Mpoya,A
AU  - Mogaka,C
AU  - Nalwanga,D
AU  - Nabawanuka,E
AU  - Nokes,J
AU  - Nyaigoti,C
AU  - Briend,A
AU  - van,Woensel JBM
AU  - Grieve,R
AU  - Sadique,Z
AU  - Williams,TN
AU  - Thomas,K
AU  - Harrison,DA
AU  - Rowan,K
AU  - Maitland,K
DO  - 10.12688/wellcomeopenres.17123.2
EP  - 221
PY  - 2021///
SN  - 2398-502X
SP  - 221
TI  - Children's Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial.
T2  - Wellcome Open Res
UR  - http://dx.doi.org/10.12688/wellcomeopenres.17123.2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34734123
UR  - https://wellcomeopenresearch.org/articles/6-221/v2
UR  - http://hdl.handle.net/10044/1/92747
VL  - 6
ER  -
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