Imperial College London
Alternate

ProfessorKathMaitland

Faculty of Medicine, Department of Surgery & Cancer

Professor of Tropical Paediatric Infectious Disease
 
 
 
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Contact

 

k.maitland CV

 
 
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Location

 

Based full-time at KEMRI/Wellcome Programme, KenyaQueen Elizabeth and Queen Mary HospitalSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Uyoga:2022:10.1038/s41467-022-30990-5,
author = {Uyoga, S and Watson, J and Wanjiku, P and Rop, J and Makale, J and Macharia, A and Kariuki, S and Nyutu, G and Shebe, M and Mosobo, M and Mturi, N and Rockett, K and Woodrow, C and Dondorp, A and Maitland, K and White, N and Williams, T},
doi = {10.1038/s41467-022-30990-5},
journal = {Nature Communications},
pages = {1--7},
title = {The impact of malaria-protective red blood cell polymorphisms on parasite biomass in children with severe Plasmodium falciparum malaria},
url = {http://dx.doi.org/10.1038/s41467-022-30990-5},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Severe falciparum malaria is a major cause of preventable child mortality in sub-Saharan Africa. Plasma concentrations of P. falciparum Histidine-Rich Protein 2 (PfHRP2) have diagnostic and prognostic value in severe malaria. We investigate the potential use of plasma PfHRP2 and the sequestration index (the ratio of PfHRP2 to parasite density) as quantitative traits for case-only genetic association studies of severe malaria. Data from 2198 Kenyan children diagnosed with severe malaria, genotyped for 14 major candidate genes, show that polymorphisms in four major red cell genes that lead to hemoglobin S, O blood group, α-thalassemia, and the Dantu blood group, are associated with substantially lower admission plasma PfHRP2 concentrations, consistent with protective effects against extensive parasitized erythrocyte sequestration. In contrast the known protective ATP2B4 polymorphism is associated with higher plasma PfHRP2 concentrations, lower parasite densities and a higher sequestration index. We provide testable hypotheses for the mechanism of protection of ATP2B4.
AU  - Uyoga,S
AU  - Watson,J
AU  - Wanjiku,P
AU  - Rop,J
AU  - Makale,J
AU  - Macharia,A
AU  - Kariuki,S
AU  - Nyutu,G
AU  - Shebe,M
AU  - Mosobo,M
AU  - Mturi,N
AU  - Rockett,K
AU  - Woodrow,C
AU  - Dondorp,A
AU  - Maitland,K
AU  - White,N
AU  - Williams,T
DO  - 10.1038/s41467-022-30990-5
EP  - 7
PY  - 2022///
SN  - 2041-1723
SP  - 1
TI  - The impact of malaria-protective red blood cell polymorphisms on parasite biomass in children with severe Plasmodium falciparum malaria
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-022-30990-5
UR  - https://www.nature.com/articles/s41467-022-30990-5
UR  - http://hdl.handle.net/10044/1/97717
VL  - 13
ER  -
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