Imperial College London
Alternate

ProfessorKathMaitland

Faculty of Medicine, Department of Surgery & Cancer

Professor of Tropical Paediatric Infectious Disease
 
 
 
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Contact

 

k.maitland CV

 
 
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Location

 

Based full-time at KEMRI/Wellcome Programme, KenyaQueen Elizabeth and Queen Mary HospitalSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Watson:2022:10.1126/scitranslmed.abn5040,
author = {Watson, J and Uyoga, S and Wanjiku, P and Makale, J and Nyutu, G and Mturi, N and George, E and Woodrow, C and Day, N and Bejon, P and Opoka, R and Dondorp, A and John, C and Maitland, K and Williams, T and White, N},
doi = {10.1126/scitranslmed.abn5040},
journal = {Science Translational Medicine},
pages = {1--10},
title = {Improving the diagnosis of severe malaria in African children using platelet counts and plasma Pf HRP2 concentrations},
url = {http://dx.doi.org/10.1126/scitranslmed.abn5040},
volume = {14},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Severe falciparum malaria is difficult to diagnose accurately in children inhigh transmission settings. Using data from 2,649 patients enrolled in fourstudies of severe illness in three countries (Bangladesh, Kenya, and Uganda),we fitted Bayesian latent class models using two diagnostic biomarkers: theplatelet count and the plasma PfHRP2 concentration. In severely ill patientswith clinical features consistent with severe malaria, a combined platelet count≤ 150,000 per µL and a plasma PfHRP2 concentration ≥ 1,000 ng/mL had anestimated sensitivity of 74% and specificity of 93% in identifying ‘true’ severefalciparum malaria. Compared to misdiagnosed children, patients with truesevere malaria had higher parasite densities, lower hematocrits, lower ratesof invasive bacterial disease, and a lower prevalence of both HbAS and HbSS.We estimate one third of African children enrolled in clinical studies of severemalaria in high transmission settings had another cause of severe illness.
AU  - Watson,J
AU  - Uyoga,S
AU  - Wanjiku,P
AU  - Makale,J
AU  - Nyutu,G
AU  - Mturi,N
AU  - George,E
AU  - Woodrow,C
AU  - Day,N
AU  - Bejon,P
AU  - Opoka,R
AU  - Dondorp,A
AU  - John,C
AU  - Maitland,K
AU  - Williams,T
AU  - White,N
DO  - 10.1126/scitranslmed.abn5040
EP  - 10
PY  - 2022///
SN  - 1946-6234
SP  - 1
TI  - Improving the diagnosis of severe malaria in African children using platelet counts and plasma Pf HRP2 concentrations
T2  - Science Translational Medicine
UR  - http://dx.doi.org/10.1126/scitranslmed.abn5040
UR  - https://www.science.org/doi/10.1126/scitranslmed.abn5040
UR  - http://hdl.handle.net/10044/1/97194
VL  - 14
ER  -
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