Imperial College London
Alternate

ProfessorKathMaitland

Faculty of Medicine, Department of Surgery & Cancer

Professor of Tropical Paediatric Infectious Disease
 
 
 
//

Contact

 

k.maitland CV

 
 
//

Location

 

Based full-time at KEMRI/Wellcome Programme, KenyaQueen Elizabeth and Queen Mary HospitalSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Walsh:2023:10.12688/wellcomeopenres.16771.2,
author = {Walsh, K and Delamare, de la Villenaise de Chenevarin G and McGurk, J and Maitland, K and Frost, G},
doi = {10.12688/wellcomeopenres.16771.2},
journal = {Wellcome Open Research},
title = {Development of a legume-enriched feed for treatment of severe acute malnutrition},
url = {http://dx.doi.org/10.12688/wellcomeopenres.16771.2},
volume = {6},
year = {2023}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Outcomes in children hospitalised with severe acute malnutrition (SAM) remain poor. The current milk-based formulations focus on restoring weight-gain but fail to address modification of the integrity of the gut barrier and may exacerbate malabsorption owing to functional lactase, maltase and sucrase deficiency. We hypothesise that nutritional feeds should be designed to promote bacterial diversity and restore gastrointestinal (GI) barrier function. Methods: Our major objective was to develop a lactose-free, fermentable carbohydrate-containing alternative to traditional F75 and F100 formulae for the inpatient treatment of SAM. New target nutritional characteristics were developed and relevant food and infant food specific legislation were reviewed. Suitable certified suppliers of ingredients were identified. Processing and manufacture steps were evaluated and optimised for safety (nutritional, chemical and microbiological), and efficacy at meeting target characteristics (lactose-free, containing resistant starch 0.4-0.5% final product weight). Results: A final validated production process was developed and implemented to produce a novel food product for the inpatient treatment of SAM in children in Africa designed to reduce risk of osmotic diarrhoea and support symbiotic gut microbial populations. The final product matched the macronutrient profile of double-concentrated F100, adhered to all relevant legislation regulating infant foods, was lactose free, and contained 0.6% resistant starch. Chickpeas were selected as the source of resistant starch, since they are widely grown and eaten throughout Africa. Micronutrient content could not be matched in this ready-to-use product, so this was replaced at the point of feeding, as was fluid lost through concentration. Conclusions: The processes and product described illustrate the development steps for a novel nutritional product. The new feed product was ready for evaluation for safety and efficacy in a phase
AU  - Walsh,K
AU  - Delamare,de la Villenaise de Chenevarin G
AU  - McGurk,J
AU  - Maitland,K
AU  - Frost,G
DO  - 10.12688/wellcomeopenres.16771.2
PY  - 2023///
SN  - 2398-502X
TI  - Development of a legume-enriched feed for treatment of severe acute malnutrition
T2  - Wellcome Open Research
UR  - http://dx.doi.org/10.12688/wellcomeopenres.16771.2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36866283
UR  - https://wellcomeopenresearch.org/articles/6-206/v2
UR  - http://hdl.handle.net/10044/1/107026
VL  - 6
ER  -
Download