Publications
240 results found
Levy MJ, Matharu MS, Powell M, et al., 2003, Phenotypic characterisation of the headache associated with pituitary tumours, 11th Congress of the International-Headache-Society, Publisher: SAGE PUBLICATIONS LTD, Pages: 621-621, ISSN: 0333-1024
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- Citations: 4
Levy MJ, Classey J, Maneersri S, et al., 2003, Differential expression of calcitonin gene-related peptide (CGRP) and substance P in pituitary adenomas: in search of a nociceptive peptide, 11th Congress of the International-Headache-Society, Publisher: SAGE PUBLICATIONS LTD, Pages: 687-687, ISSN: 0333-1024
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- Citations: 1
Levy MJ, Bejon P, Barakat M, et al., 2003, Acromegaly: A unique human headache model, HEADACHE, Vol: 43, Pages: 794-797, ISSN: 0017-8748
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- Citations: 20
Park A, Edwards M, Donaldson M, et al., 2003, Lesson of the week - Interfering antibodies affecting immunoassays in woman with pet rabbits, BRITISH MEDICAL JOURNAL, Vol: 326, Pages: 541-542, ISSN: 0959-535X
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- Citations: 7
Todd JF, Stanley SA, Roufosse CA, et al., 2003, A tumour that secretes glucagon-like peptide-1 and somatostatin in a patient with reactive hypoglycaemia and diabetes, Lancet, Vol: 361, Pages: 228-230
Glucagon-like peptide 1 (GLP-1), an insulinotropic hormone normally synthesised in the intestinal mucosa and released in response to a meal, is essential for normal glucose homoeostasis. There is much interest in the use of GLP-1 to treat diabetes, since the risk of hypoglycaemia is thought to be low. We report an instance of a 45-year-old woman with a GLP-1 and somatostatin secreting neuroendocrine tumour who presented with reactive hypoglycaemia and hyperglycaemia, but who was subsequently cured by surgery. This case, of a neuroendocrine tumour secreting GLP-1 and causing reactive hypoglycaemia, indicates a potential adverse effect of GLP-1 therapy for diabetes
turner jj, wren am, jackson je, et al., 2002, Localization of gastrinomas by selective intra-arterial calcium injection, Clin Endocrinol (Oxf), Vol: 57, Pages: 821-825, ISSN: 0300-0664
Savage DB, Agostini M, Barroso I, et al., 2002, Digenic inheritance of severe insulin resistance in a human pedigree (vol 31, pg 379, 2002), NATURE GENETICS, Vol: 32, Pages: 211-211, ISSN: 1061-4036
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- Citations: 1
Savage DB, Agostini M, Barroso I, et al., 2002, Digenic inheritance of severe insulin resistance in a human pedigree, NATURE GENETICS, Vol: 31, Pages: 379-384, ISSN: 1061-4036
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- Citations: 115
Savage DB, Agostini M, Barroso I, et al., 2002, A digenic disorder of human insulin action, DIABETES, Vol: 51, Pages: A303-A303, ISSN: 0012-1797
Murphy E, Bassett JD, Meeran K, et al., 2002, The efficacy of radioiodine in thyrotoxicosis is enhanced by lithium carbonate., JOURNAL OF NUCLEAR MEDICINE, Vol: 43, Pages: 318P-318P, ISSN: 0161-5505
Parkinson C, Drake WM, Roberts ME, et al., 2002, A comparison of the effects of pegvisomant and octreotide on glucose, insulin, gastrin, cholecystokinin and pancreatic polypeptide responses to oral glucose and a standard mixed meal, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 87, Pages: 1797-1804, ISSN: 0021-972X
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- Citations: 66
le Roux CW, Meeran K, Alaghband-Zadeh J, 2002, Is a 0900-h serum cortisol useful prior to a short Synacthen test in outpatient assessment?, ANNALS OF CLINICAL BIOCHEMISTRY, Vol: 39, Pages: 148-150, ISSN: 0004-5632
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- Citations: 53
Dhillo WS, Kong WM, Le Roux CW, et al., 2002, Cortisol-binding globulin is important in the interpretation of dynamic tests of the hypothalamic-pituitary-adrenal axis, EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol: 146, Pages: 231-235, ISSN: 0804-4643
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- Citations: 66
le Roux CW, Mulla A, Meeran K, 2001, Pituitary carcinoma as a cause of acromegaly, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 345, Pages: 1645-1646, ISSN: 0028-4793
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- Citations: 12
Taheri S, Meeran K, 2000, Islet cell tumours: diagnosis and medical management, HOSPITAL MEDICINE, Vol: 61, Pages: 824-+, ISSN: 1462-3935
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- Citations: 2
Todd JF, Meeran K, 2000, The tumour vanishes, CLINICAL ENDOCRINOLOGY, Vol: 53, Pages: 663-664, ISSN: 0300-0664
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- Citations: 2
Sofat N, Turner J, Khoo B, et al., 2000, An unusual cause of Cushing's syndrome: Primary pigmented nodular adrenal dysplasia, INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Vol: 54, Pages: 269-271, ISSN: 1368-5031
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- Citations: 1
Goodlad RA, Mandir N, Meeran K, et al., 2000, Does the response of the intestinal epithelium to keratinocyte growth factor vary according to the method of administration?, REGULATORY PEPTIDES, Vol: 87, Pages: 83-90, ISSN: 0167-0115
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- Citations: 15
Rajkumar C, Mensah R, Meeran K, et al., 1999, Peripheral arterial compliance is lower in Afro-Caribbeans compared to white Caucasians with type 2 diabetes after adjustment for blood pressure, JOURNAL OF HUMAN HYPERTENSION, Vol: 13, Pages: 841-843, ISSN: 0950-9240
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- Citations: 19
Meeran K, O'Shea D, Edwards CM, et al., 1999, Repeated Intracerebroventricular Administration of Glucagon-Like Peptide-1-(7-36) Amide or Exendin-(9-39) Alters Body Weight in the Rat* *This work was supported by the United Kingdom Medical Research Council., Endocrinology, Vol: 140, Pages: 244-250
Meeran K, O'Shea D, Edwards CMB, et al., 1999, Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat, ENDOCRINOLOGY, Vol: 140, Pages: 244-250, ISSN: 0013-7227
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- Citations: 255
Pearce SHS, Cheetham T, Imrie H, et al., 1998, A common and recurrent 13-bp deletion in the autoimmune regulator gene in British kindreds with autoimmune polyendocrinopathy type 1, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 63, Pages: 1675-1684, ISSN: 0002-9297
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- Citations: 144
Morgan DGA, Small CJ, Abusnana S, et al., 1998, The NPY Y1 receptor antagonist BIBP 3226 blocks NPY induced feeding via a non-specific mechanism, REGULATORY PEPTIDES, Vol: 75-6, Pages: 377-382, ISSN: 0167-0115
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- Citations: 45
Playford RJ, Marchbank T, Mandir N, et al., 1998, Effects of keratinocyte growth factor (KGF) on gut growth and repair, JOURNAL OF PATHOLOGY, Vol: 184, Pages: 316-322, ISSN: 0022-3417
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- Citations: 40
Playford RJ, Marchbank T, Mandir N, et al., 1998, Effects of keratinocyte growth factor (KGF) on gut growth and repair, Journal of Pathology, Vol: 184, Pages: 316-322, ISSN: 0022-3417
Keratinocyte growth factor (KGF) is a mitogen found throughout the gastrointestinal tract, but its role in gastrointestinal pathophysiology is unclear. The effect of recombinant KGF on gut growth and repair has been examined using a variety of in vivo models. Rats receiving total parenteral nutrition had co-infusions of KGF or control for 6 days. Changes in gut growth (wet weight and vincristine-induced metaphase arrest) were then assessed. The effects of KGF on gastric repair and acid secretion in rats were determined using an indomethacin (20 mg/kg)/restraint model and animals fitted with chronic gastric fistulae. KGF at 0.1, 1, and 3 mg/kg increased gut growth as assessed by wet weight throughout the gastrointestinal tract and increased vincristine-induced accumulation of metaphases in the stomach and small intestine but not in the colon. Plasma gastrin, peptide YY, enteroglucagon, and glucagon-like peptide-1 were all increased, whereas insulin was lowered by KGF (all P<0.01). KGF was ineffective in reducing indomethacin-induced gastric damage but caused a reduction in basal acid secretion of about 35 and 50 per cent when administered at 0.2 or 5 mg/kg (P<0.05). These studies support the idea that KGF is involved in the control of proliferation of the gastrointestinal tract. They do not provide evidence, however, for a role in the early reparative process invoked during short- term models of gastrointestinal injury.
Small CJ, Morgan DGA, Meeran K, et al., 1997, Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 94, Pages: 11686-11691, ISSN: 0027-8424
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- Citations: 54
Desai M, Byrne CD, Meeran K, et al., 1997, Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Vol: 273, Pages: G899-G904, ISSN: 0193-1857
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- Citations: 89
Goldstone AP, Mercer JG, Gunn I, et al., 1997, Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents, FEBS LETTERS, Vol: 415, Pages: 134-138, ISSN: 0014-5793
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- Citations: 120
Desai M, Byrne CD, Meeran K, et al., 1997, Cafeteria diet causes features of insulin resistance in maternal protein-restricted rat offspring, DIABETOLOGIA, Vol: 40, Pages: 1117-1117, ISSN: 0012-186X
Turton M, Edwards CM, Meeran K, et al., 1997, Chronic intracerebroventricular administration of GLP-1 reduces body weight in rats., DIABETES, Vol: 46, Pages: 711-711, ISSN: 0012-1797
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