Imperial College London
Alternate

Professor Karim Meeran

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Endocrinology
 
 
 
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Contact

 

+44 (0)20 8846 1065k.meeran

 
 
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Location

 

9E05Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Khoo:2021:clinem/dgaa830,
author = {Khoo, B and Tan, T and Clarke, S and Mills, E and Patel, B and Modi, M and Phylactou, M and Eng, PC and Thurston, L and Alexander, E and Meeran, K and Comninos, A and Abbara, A and Dhillo, W},
doi = {clinem/dgaa830},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {e803--e811},
title = {Thyroid function before, during and after COVID-19},
url = {http://dx.doi.org/10.1210/clinem/dgaa830},
volume = {106},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Context: The effects of COVID-19 on the thyroid axis remain uncertain. Recent evidence has been conflicting, with both thyrotoxicosis and suppression of thyroid function reported. Objective: We aimed to detail the acute effects of COVID-19 on thyroid function and determine if these effects persisted upon recovery from COVID-19.  Design: Cohort observational study. Participants and setting: Adult patients admitted to Imperial College Healthcare National Health Service Trust, London, UK with suspected COVID-19 between March 9 to April 22, 2020 were included, excluding those with pre-existing thyroid disease and those missing either free thyroxine (FT4) or TSH measurements. Of 456 patients, 334 had COVID-19 and 122 did not.Main Outcome Measures: TSH and FT4 measurements at admission, and where available, those taken in 2019 and at COVID-19 follow-up. Results: Most patients (86·6%) presenting with COVID-19 were euthyroid, with none presenting with overt thyrotoxicosis. Patients with COVID-19 had a lower admission TSH and FT4 compared to those without COVID-19. In the COVID-19 patients with matching baseline thyroid function tests from 2019 (n=185 for TSH and 104 for FT4), both TSH and FT4 were reduced at admission compared to baseline. In a complete cases analysis of COVID-19 patients with TSH measurements at follow-up, admission and baseline (n=55), TSH was seen to recover to baseline at follow-up. Conclusions: Most patients with COVID-19 present with euthyroidism. We observed mild reductions in TSH and FT4 in keeping with a non-thyroidal illness syndrome. Furthermore, in survivors of COVID-19, thyroid function tests at follow-up returned to baseline.
AU  - Khoo,B
AU  - Tan,T
AU  - Clarke,S
AU  - Mills,E
AU  - Patel,B
AU  - Modi,M
AU  - Phylactou,M
AU  - Eng,PC
AU  - Thurston,L
AU  - Alexander,E
AU  - Meeran,K
AU  - Comninos,A
AU  - Abbara,A
AU  - Dhillo,W
DO  - clinem/dgaa830
EP  - 811
PY  - 2021///
SN  - 0021-972X
SP  - 803
TI  - Thyroid function before, during and after COVID-19
T2  - Journal of Clinical Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1210/clinem/dgaa830
UR  - https://academic.oup.com/jcem/article/106/2/e803/5979483
UR  - http://hdl.handle.net/10044/1/83698
VL  - 106
ER  -
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