Imperial College London
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DrKevinMonahan

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

k.monahan Website

 
 
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Location

 

CRUKSt Marks HospitalNorthwick Park and St Marks Site

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Summary

 

Publications

Citation

BibTex format

@article{Aggarwal:2021:10.1007/s00384-021-04046-x,
author = {Aggarwal, N and Quaglia, A and McPhail, MJW and Monahan, KJ},
doi = {10.1007/s00384-021-04046-x},
journal = {International Journal of Colorectal Disease: clinical and molecular gastroenterology and surgery},
pages = {35--46},
title = {Systematic review and meta-analysis of tumour microsatellite-instability status as a predictor of response to fluorouracil-based adjuvant chemotherapy in colorectal cancer},
url = {http://dx.doi.org/10.1007/s00384-021-04046-x},
volume = {37},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeColorectal cancer (CRC) can be classified according to the chromosomal-instability pathway (a microsatellite-stable (MSS) pathway) and the microsatellite-instability (MSI) pathway. Adjuvant therapy after surgery in advanced CRC is usually based on fluoropyrimidine 5-fluorouracil (5-FU) alone or combined with other agents. Controversy however remains on the use of 5-FU-based regimens in treating MSI-related tumours.AimsTo systematically investigate the relationship between tumour microsatellite profile and 5-year overall survival in patients with CRC treated with 5-FU.MethodsA systematic literature review of PubMed and Embase databases was conducted. Pre-specified criteria determined study inclusion/exclusion. The PRISMA and QUADAS-2 criteria were used to assess study suitability and quality respectively. Patients were categorised as having either MSI or MSS CRC. Overall 5-year survival was estimated from Kaplan–Meier curves. Publication bias was assessed using funnel-plots and Egger’s test.Results1807 studies were identified, with meta-analysis performed using nine studies. 5-FU treated individuals with CRC who died at 5 years were found to be 0.31 times less likely to have MSI than those who were alive, although this was not statistically significant. There was an insufficient number of studies to enable subgroup analysis by stage.ConclusionsIn this meta-analysis, MSI status does not alter 5-year survival of patients with CRC patients treated with adjuvant 5-FU, however there is significant heterogeneity in the design of individual studies in the data synthesis. More studies are necessary to clarify whether CRC patients with MSI CRC, in particular early stage, should be offered 5-FU based adjuvant chemotherapy.
AU  - Aggarwal,N
AU  - Quaglia,A
AU  - McPhail,MJW
AU  - Monahan,KJ
DO  - 10.1007/s00384-021-04046-x
EP  - 46
PY  - 2021///
SN  - 0179-1958
SP  - 35
TI  - Systematic review and meta-analysis of tumour microsatellite-instability status as a predictor of response to fluorouracil-based adjuvant chemotherapy in colorectal cancer
T2  - International Journal of Colorectal Disease: clinical and molecular gastroenterology and surgery
UR  - http://dx.doi.org/10.1007/s00384-021-04046-x
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000710044600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007/s00384-021-04046-x
UR  - http://hdl.handle.net/10044/1/100511
VL  - 37
ER  -
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