Imperial College London

DrKarenMosley

Faculty of MedicineNational Heart & Lung Institute

CRF General Manager
 
 
 
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Contact

 

+44 (0)20 3313 8073k.mosley

 
 
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Location

 

NIHR Imperial CRFICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

19 results found

Mosley K, Tam FWK, Edwards RJ, Crozier J, Pusey CD, Lightstone Let al., 2006, Urinary proteomic profiles distinguish between active and inactive lupus nephritis, RHEUMATOLOGY, Vol: 45, Pages: 1497-1504, ISSN: 1462-0324

Journal article

Karen Mosley, Liz Lightstone, Robert Edwards, Jo Crozier, Charles Puseyet al., 2005, Urinary proteomic profiles are able to discriminate between active and inactive lupus nephritis, The American Society of Nephrology

Conference paper

Waddington SN, Nivsarkar MS, Mistry AR, Buckley SMK, Kemball-Cook G, Mosley KL, Mitrophanous K, Radcliffe P, Holder MV, Brittan M, Georgiadis A, Al-Allaf F, Bigger BW, Gregory LG, Cook HT, Ali RR, Thrasher A, Tuddenham EGD, Themis M, Coutelle Cet al., 2004, Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy, BLOOD, Vol: 104, Pages: 2714-2721, ISSN: 0006-4971

Journal article

Waddington SN, Nivsarkar M, Mistry A, Buckley SMK, Kemball-Cook G, Mosley KL, Mitrophanous K, Radcliffe P, Holder M, Brittan M, Georgiadis T, Al-Allaf F, Bigger B, Gregory L, Cook HT, Ali RR, Thrasher A, Tuddenham EGD, Themis M, Coutelle Cet al., 2004, Permanent phenotypic correction of Haemophilia B in immunocompetent mice by prenatal gene therapy, 1st Annual Conference of the British-Society-for-Gene-Therapy, Publisher: WILEY-BLACKWELL, Pages: S17-S17, ISSN: 1099-498X

Conference paper

Gregory LG, Waddington SN, Holder MV, Mitrophanous KA, Buckley SMK, Mosley KL, Bigger BW, Ellard FM, Walmsley LE, Lawrence L, Al-Allaf F, Kingsman S, Coutelle C, Themis Met al., 2004, Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy, GENE THERAPY, Vol: 11, Pages: 1117-1125, ISSN: 0969-7128

Journal article

Waddington SN, Nivsarkar MS, Mistry AR, Buckley SMK, Kemball-Cook G, Mosley KL, Mitrophanous K, Radcliffe P, Holder MV, Brittan M, Georgiadis T, Al-Allaf F, Bigger BW, Gregory LG, Cook TH, Ali RR, Thrasher A, Tuddenham EGD, Themis M, Coutelle Cet al., 2004, Permanent phenotypic correction of haemophilia B in immunocompetent mice by prenatal gene therapy, 7th Annual Meeting of the American-Society-of-Gene-Therapy, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S15-S15, ISSN: 1525-0016

Conference paper

Salama AD, Chaudhry AN, Holthaus KA, Mosley K, Kalluri R, Sayegh MH, Lechler RI, Pusey CD, Lightstone Let al., 2003, Regulation by CD25<SUP>+</SUP> lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease, KIDNEY INTERNATIONAL, Vol: 64, Pages: 1685-1694, ISSN: 0085-2538

Journal article

Lightstone L, Salama A, Mosley K, Chaudhry A, Pusey C, Lechler Ret al., 2001, Regulatory T cell populations in Goodpasture's disease and Alport's syndrome, J Am Soc Nephrol, Vol: 12

Journal article

Mosley K, Collar J, Cattell V, 2000, Mesangial cell necrosis in Thy 1 glomerulonephritis - an ultrastructural study, VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, Vol: 436, Pages: 567-573, ISSN: 0945-6317

Journal article

Waddington SN, Mosley K, Cattell V, 1999, Induced nitric oxide (NO) synthesis in heterologous nephrotoxic nephritis; effects of selective inhibition in neutrophil-dependent glomerulonephritis, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 118, Pages: 309-314, ISSN: 0009-9104

Journal article

Waddington S, Cook T, Ebrahim H, Mosley K, Cattell Vet al., 1999, Antioxidant treatment suppresses injury and iNOS induction in Thy 1 glomerulonephritis (gn)., KIDNEY INTERNATIONAL, Vol: 55, Pages: 2106-2106, ISSN: 0085-2538

Journal article

Mosley K, Waddington SN, Ebrahim H, Cook T, Cattell Vet al., 1999, Inducible nitric oxide synthase induction in Thy 1 glomerulonephritis is complement and reactive oxygen species dependent, EXPERIMENTAL NEPHROLOGY, Vol: 7, Pages: 26-34, ISSN: 1018-7782

Journal article

Waddington SN, Mosley K, Cook HT, Tam FWK, Cattell Vet al., 1998, Arginase AI Is upregulated in acute immune complex-induced inflammation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 247, Pages: 84-87, ISSN: 0006-291X

Journal article

Mosley K, Wembridge DE, Cattell V, Cook HTet al., 1998, Heme oxygenase is induced in nephrotoxic nephritis and hemin, a stimulator of heme oxygenase synthesis, ameliorates disease, KIDNEY INTERNATIONAL, Vol: 53, Pages: 672-678, ISSN: 0085-2538

Journal article

Cattell V, Mosley K, 1998, Immunohistochemical localization of NOS isoforms., Methods Mol Biol, Vol: 100, Pages: 181-189, ISSN: 1064-3745

Journal article

Cook T, Mosley K, Cattell V, 1997, Hemin, an inducer of haem oxygenase, ameliorates experimental nephrotoxic nephritis, KIDNEY INTERNATIONAL, Vol: 52, Pages: 261-261, ISSN: 0085-2538

Journal article

Mosley K, Cuzner ML, 1996, Receptor-mediated phagocytosis of myelin by macrophages and microglia: effect of opsonization and receptor blocking agents., Neurochem Res, Vol: 21, Pages: 481-487, ISSN: 0364-3190

Myelin is phagocytosed by microglia (MG) and to a somewhat lesser extent by peritoneal macrophages (M phi) in a dose- and time-dependent manner. In serum-free medium opsonization of rat myelin significantly enhances binding and ingestion, more by rat macrophages than by microglia. Furthermore the requirement for opsonization is not restricted to anti-myelin antibodies as the difference in the rate of myelin uptake by macrophages is largely eliminated when they are cultured in 10% fetal calf serum. Binding and ingestion of both myelin and opsonized myelin are inhibited to the same dose-dependent extent by zymosan, oxidized LDL, peroxidase-antiperoxidase (PAP), opsonized erythrocytes and the anti-CR3 antibody OX42 implicating lectin, scavenger, Fc and complement receptors in the phagocytosis of myelin. Thus while the differential uptake of myelin and opsonized myelin by macrophages would indicate a central role for the Fc receptor, binding inhibition studies implicate a range of membrane receptors which would obviate the need for antigen-antibody complexing to stimulate phagocytosis. Uptake of both myelin preparations by macrophages or microglia is stimulated by interferon-gamma and inhibited by TGF-beta, and the process of ingestion results in increased nitric oxide release and decreased superoxide production, the effect being more pronounced when myelin is opsonized.

Journal article

Cuzner ML, Loughlin AJ, Mosley K, Woodroofe MNet al., 1994, The role of microglia macrophages in the processes of inflammatory demyelination and remyelination., Neuropathol Appl Neurobiol, Vol: 20, Pages: 200-201, ISSN: 0305-1846

Journal article

Salama A, Pusey C, Jayne D, Mosley Ket al., ABAVAS: A trial of CTLA4Ig in ANCA vasculitis, CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol: 25, Pages: S114-S114, ISSN: 0392-856X

Journal article

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