Publications
19 results found
Mosley K, Tam FWK, Edwards RJ, et al., 2006, Urinary proteomic profiles distinguish between active and inactive lupus nephritis, RHEUMATOLOGY, Vol: 45, Pages: 1497-1504, ISSN: 1462-0324
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- Citations: 70
Karen Mosley, Liz Lightstone, Robert Edwards, et al., 2005, Urinary proteomic profiles are able to discriminate between active and inactive lupus nephritis, The American Society of Nephrology
Waddington SN, Nivsarkar MS, Mistry AR, et al., 2004, Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy, BLOOD, Vol: 104, Pages: 2714-2721, ISSN: 0006-4971
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- Citations: 100
Waddington SN, Nivsarkar M, Mistry A, et al., 2004, Permanent phenotypic correction of Haemophilia B in immunocompetent mice by prenatal gene therapy, 1st Annual Conference of the British-Society-for-Gene-Therapy, Publisher: WILEY-BLACKWELL, Pages: S17-S17, ISSN: 1099-498X
Gregory LG, Waddington SN, Holder MV, et al., 2004, Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy, GENE THERAPY, Vol: 11, Pages: 1117-1125, ISSN: 0969-7128
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- Citations: 32
Waddington SN, Nivsarkar MS, Mistry AR, et al., 2004, Permanent phenotypic correction of haemophilia B in immunocompetent mice by prenatal gene therapy, 7th Annual Meeting of the American-Society-of-Gene-Therapy, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S15-S15, ISSN: 1525-0016
Salama AD, Chaudhry AN, Holthaus KA, et al., 2003, Regulation by CD25<SUP>+</SUP> lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease, KIDNEY INTERNATIONAL, Vol: 64, Pages: 1685-1694, ISSN: 0085-2538
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- Citations: 90
Lightstone L, Salama A, Mosley K, et al., 2001, Regulatory T cell populations in Goodpasture's disease and Alport's syndrome, J Am Soc Nephrol, Vol: 12
Mosley K, Collar J, Cattell V, 2000, Mesangial cell necrosis in Thy 1 glomerulonephritis - an ultrastructural study, VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, Vol: 436, Pages: 567-573, ISSN: 0945-6317
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- Citations: 15
Waddington SN, Mosley K, Cattell V, 1999, Induced nitric oxide (NO) synthesis in heterologous nephrotoxic nephritis; effects of selective inhibition in neutrophil-dependent glomerulonephritis, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 118, Pages: 309-314, ISSN: 0009-9104
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- Citations: 10
Waddington S, Cook T, Ebrahim H, et al., 1999, Antioxidant treatment suppresses injury and iNOS induction in Thy 1 glomerulonephritis (gn)., KIDNEY INTERNATIONAL, Vol: 55, Pages: 2106-2106, ISSN: 0085-2538
Mosley K, Waddington SN, Ebrahim H, et al., 1999, Inducible nitric oxide synthase induction in Thy 1 glomerulonephritis is complement and reactive oxygen species dependent, EXPERIMENTAL NEPHROLOGY, Vol: 7, Pages: 26-34, ISSN: 1018-7782
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- Citations: 28
Waddington SN, Mosley K, Cook HT, et al., 1998, Arginase AI Is upregulated in acute immune complex-induced inflammation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 247, Pages: 84-87, ISSN: 0006-291X
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- Citations: 35
Mosley K, Wembridge DE, Cattell V, et al., 1998, Heme oxygenase is induced in nephrotoxic nephritis and hemin, a stimulator of heme oxygenase synthesis, ameliorates disease, KIDNEY INTERNATIONAL, Vol: 53, Pages: 672-678, ISSN: 0085-2538
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- Citations: 84
Cattell V, Mosley K, 1998, Immunohistochemical localization of NOS isoforms., Methods Mol Biol, Vol: 100, Pages: 181-189, ISSN: 1064-3745
Cook T, Mosley K, Cattell V, 1997, Hemin, an inducer of haem oxygenase, ameliorates experimental nephrotoxic nephritis, KIDNEY INTERNATIONAL, Vol: 52, Pages: 261-261, ISSN: 0085-2538
Mosley K, Cuzner ML, 1996, Receptor-mediated phagocytosis of myelin by macrophages and microglia: effect of opsonization and receptor blocking agents., Neurochem Res, Vol: 21, Pages: 481-487, ISSN: 0364-3190
Myelin is phagocytosed by microglia (MG) and to a somewhat lesser extent by peritoneal macrophages (M phi) in a dose- and time-dependent manner. In serum-free medium opsonization of rat myelin significantly enhances binding and ingestion, more by rat macrophages than by microglia. Furthermore the requirement for opsonization is not restricted to anti-myelin antibodies as the difference in the rate of myelin uptake by macrophages is largely eliminated when they are cultured in 10% fetal calf serum. Binding and ingestion of both myelin and opsonized myelin are inhibited to the same dose-dependent extent by zymosan, oxidized LDL, peroxidase-antiperoxidase (PAP), opsonized erythrocytes and the anti-CR3 antibody OX42 implicating lectin, scavenger, Fc and complement receptors in the phagocytosis of myelin. Thus while the differential uptake of myelin and opsonized myelin by macrophages would indicate a central role for the Fc receptor, binding inhibition studies implicate a range of membrane receptors which would obviate the need for antigen-antibody complexing to stimulate phagocytosis. Uptake of both myelin preparations by macrophages or microglia is stimulated by interferon-gamma and inhibited by TGF-beta, and the process of ingestion results in increased nitric oxide release and decreased superoxide production, the effect being more pronounced when myelin is opsonized.
Cuzner ML, Loughlin AJ, Mosley K, et al., 1994, The role of microglia macrophages in the processes of inflammatory demyelination and remyelination., Neuropathol Appl Neurobiol, Vol: 20, Pages: 200-201, ISSN: 0305-1846
Salama A, Pusey C, Jayne D, et al., ABAVAS: A trial of CTLA4Ig in ANCA vasculitis, CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol: 25, Pages: S114-S114, ISSN: 0392-856X
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