Publications
421 results found
Menter T, Trivedi P, Ahmad R, et al., 2017, Diagnostic Utility of Lymphoid Enhancer Binding Factor 1 Immunohistochemistry in Small B-Cell Lymphomas, AMERICAN JOURNAL OF CLINICAL PATHOLOGY, Vol: 147, Pages: 292-300, ISSN: 0002-9173
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- Citations: 15
Disanto MG, Ambrosio MR, Rocca BJ, et al., 2016, Optimal Minimal Panels of Immunohistochemistry for Diagnosis of B-Cell Lymphoma for Application in Countries With Limited Resources and for Triaging Cases Before Referral to Specialist Centers, AMERICAN JOURNAL OF CLINICAL PATHOLOGY, Vol: 145, Pages: 687-695, ISSN: 0002-9173
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- Citations: 7
Ibrahim HAH, Balachandran K, Bower M, et al., 2016, Bone marrow manifestations in multicentric Castleman disease, British Journal of Haematology, Vol: 172, Pages: 923-929, ISSN: 1365-2141
This study aimed to document the morphological and immunophenotypic features, and describe the diagnostic features of bone marrow (BM) involvement in human herpes virus 8 Multicentric Castleman disease (HHV8-MCD). BM trephine biopsy (BMTB) specimens from 28 patients were revisited. Samples were evaluated for expression of CD3, CD20, CD138, CD68R, glycophorin C, CD42b, HHV8-latency-associated nuclear antigen (LANA1), Epstein–Barr virus-encoded small RNA and light chains. Presence of significant numbers of HHV8-LANA1+ lymphoid/plasmacytic cells, noted in 10/28 cases, was indicative of BM involvement and was associated with low CD4 and CD8 counts in peripheral blood. The characteristic morphological appearance of MCD seen in lymph nodes is a rare finding in BMTB. 4/5 cases with lymphoid aggregates were involved by MCD, whereas 6/23 cases without lymphoid aggregates were involved by MCD (P = 0·023). 9/18 cases with hypercellular marrow were involved by MCD, whilst only 1/8 cases with normo/hypocellular marrow showed involvement by MCD (P = 0·070). While 9/21 cases with increased marrow reticulin were involved by MCD, none of the cases with no increase in reticulin were involved by MCD (P = 0·080). Reactive plasmacytosis is a frequent finding. We conclude that bone marrow is involved in a significant proportion of patients with MCD (36%), and involvement can be identified by HHV8-LANA1 immunohistochemistry.
Smith T, Mauri F, Naresh KN, 2016, Thyroid transcription factor-1 immunostaining in World Health Organization type AB thymoma, HISTOPATHOLOGY, Vol: 68, Pages: 618-619, ISSN: 0309-0167
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- Citations: 1
Johnston AC, Naresh K, Barwick T, et al., 2015, Cutaneous presentation of an aggressive plasmablastic neoplasm indiscriminate between lymphoma and myeloma, ANNALS OF HEMATOLOGY, Vol: 94, Pages: 691-692, ISSN: 0939-5555
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- Citations: 3
Greenough A, Moffitt A, Jima D, et al., 2014, Strand-Specific Total RNA Sequencing Establishes the Complete Transcriptome and Alternative Splicing Repertoire in Diffuse Large B Cell Lymphoma, 56th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
Koulis A, Trivedi P, Ibrahim H, et al., 2014, The role of the microenvironment in human immunodeficiency virus-associated classical Hodgkin lymphoma, HISTOPATHOLOGY, Vol: 65, Pages: 749-756, ISSN: 0309-0167
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- Citations: 9
Naresh KN, Barwick T, Karadimitris A, 2014, IgG4 positive mucosa associated lymphoid tissue lymphoma of the orbit - lesson of the month, HISTOPATHOLOGY, Vol: 65, Pages: 718-721, ISSN: 0309-0167
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- Citations: 9
Ahearne MJ, Bhuller K, Hew R, et al., 2014, Expression of PD-1 (CD279) and FoxP3 in diffuse large B-cell lymphoma, VIRCHOWS ARCHIV, Vol: 465, Pages: 351-358, ISSN: 0945-6317
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- Citations: 58
Ibrahim H, Naresh K, Bower M, et al., 2014, Bone marrow manifestations in Multicentric Castleman Disease, VIRCHOWS ARCHIV, Vol: 465, Pages: S274-S274, ISSN: 0945-6317
Koulis A, Trivedi P, Ibrahim H, et al., 2014, The role of the micro-environment in human immunodeficiency virus-associated classical Hodgkin Lymphoma, VIRCHOWS ARCHIV, Vol: 465, Pages: S267-S267, ISSN: 0945-6317
Smith T, Mauri F, Naresh K, 2014, TTF-1 expression discriminates thymoma type AB from other thymomas, VIRCHOWS ARCHIV, Vol: 465, Pages: S335-S335, ISSN: 0945-6317
Lee J, Ibrahim H, MacDonald D, et al., 2014, A snapshot of changing trends in EBV Association among Burkitt Lymphoma and B-cell Lymphoma, unclassifiable (intermediate between diffuse large B-cell Lymphoma and Burkitt Lymphoma): A perspective of a UK Tertiary Academic Referral Centre, VIRCHOWS ARCHIV, Vol: 465, Pages: S28-S28, ISSN: 0945-6317
Oduwole OO, Vydra N, Wood NEM, et al., 2014, Overlapping dose responses of spermatogenic and extragonadal testosterone actions jeopardize the principle of hormonal male contraception, FASEB JOURNAL, Vol: 28, Pages: 2566-2576, ISSN: 0892-6638
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- Citations: 17
Bower M, Dalla Pria A, Coyle C, et al., 2014, Diagnostic Criteria Schemes for Multicentric Castleman Disease in 75 Cases, JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 65, Pages: E80-E82, ISSN: 1525-4135
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- Citations: 13
Martin TCS, Martin NK, Naresh KN, et al., 2013, Atraumatic splenic rupture secondary to chronic HIV infection, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 24, Pages: 989-991, ISSN: 0956-4624
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- Citations: 1
Robin F, Ale S, Patel A, et al., 2013, Targeted High-Throughput Sequencing For The Detection Of Mutations Associated With Myeloproliferative Neoplasms, 55th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
Scotland P, Gaulard P, Love CL, et al., 2013, Whole Genome and Exome Sequencing Defines The Genetic Landscape Of Hepatosplenic T-Cell Lymphoma, 55th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
Onubogu IK, Cooper N, Naresh K, et al., 2013, Alternative Methods Of Thrombocytopenia: Patients With ITP Have Increased Megakaryocyte/T Cell Interactions In The Bone Marrow and Higher Serum TRAIL Levels, 55th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
Barbarulo A, Iansante V, Chaidos A, et al., 2013, Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma, Oncogene, Vol: 32, Pages: 4231-4242, ISSN: 0950-9232
Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM). Jun N-terminal kinase (JNK) signaling has been implicated in MM pathogenesis, but its function is unclear. To elucidate the role of JNK in MM, we evaluated the specific functions of the two major JNK proteins, JNK1 and JNK2. We show here that JNK2 is constitutively activated in a panel of MM cell lines and primary tumors. Using loss-of-function studies, we demonstrate that JNK2 is required for the survival of myeloma cells and constitutively suppresses JNK1-mediated apoptosis by affecting expression of poly(ADP-ribose) polymerase (PARP)14, a key regulator of B-cell survival. Strikingly, we found that PARP14 is highly expressed in myeloma plasma cells and associated with disease progression and poor survival. Overexpression of PARP14 completely rescued myeloma cells from apoptosis induced by JNK2 knockdown, indicating that PARP14 is critically involved in JNK2-dependent survival. Mechanistically, PARP14 was found to promote the survival of myeloma cells by binding and inhibiting JNK1. Moreover, inhibition of PARP14 enhances the sensitization of MM cells to anti-myeloma agents. Our findings reveal a novel regulatory pathway in myeloma cells through which JNK2 signals cell survival via PARP14, and identify PARP14 as a potential therapeutic target in myeloma.
Ali H, Naresh K, Aqel NM, 2013, Primary nodular lymphocyte predominant Hodgkin lymphoma of the palate: a rare incidence which was also associated with progressive transformation of germinal centres of cervical lymph node., J Egypt Natl Canc Inst, Vol: 25, Pages: 161-163
Primary manifestation of nodular lymphocyte predominant Hodgkin lymphoma in oral cavity is very rare. We are describing such a case which was associated with progressive transformation of germinal centres in a cervical lymph node.
Abdulsalam AH, Nadal-Melsio E, Naresh KN, 2013, Complementarity of Evaluation of Myeloperoxidase Expression by Flow Cytometry and Immunohistochemistry on Bone Marrow Trephine Biopsy Sections in Acute Myeloid Leukemia, CYTOMETRY PART B-CLINICAL CYTOMETRY, Vol: 86, Pages: 70-73, ISSN: 1552-4949
Hashimabdulsalam A, Nadal-Melsio E, Naresh KN, 2013, Complementarity of evaluation of myeloperoxidase expression by flow cytometry and immunohistochemistry on bone marrow trephine biopsy sections in acute myeloid leukaemia., Cytometry B Clin Cytom
De Falco G, Ambrosio MR, Piccaluga PP, et al., 2013, The alteration of lipid metabolism in Burkitt lymphoma identifies a novel marker: Adipophilin, Publisher: SPRINGER, Pages: 136-136, ISSN: 0945-6317
Bull L, Knowles A, Ogden S, et al., 2013, Primary cervical lymphoma: a rare presentation to a genitourinary medicine clinic, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 24, Pages: 587-589, ISSN: 0956-4624
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- Citations: 7
Patel A, Valganon M, Foong HE, et al., 2013, CUSTOM AMPLICON CAPTURE AND BENCH-TOP HIGH THROUGHPUT SEQUENCING TO SCREEN FOR MUTATIONS ASSOCIATED WITH MYELOPROLIFERATIVE NEOPLASMS, Publisher: FERRATA STORTI FOUNDATION, Pages: 111-111, ISSN: 0390-6078
Bain BJ, Garnett C, Deplano S, et al., 2013, Dysplasia of all granulocyte lineages in myelodysplastic evolution of essential thrombocythemia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 88, Pages: 426-426, ISSN: 0361-8609
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- Citations: 1
Herbst S, Shah A, Carby M, et al., 2013, A new and clinically relevant murine model of solid-organ transplant aspergillosis, DISEASE MODELS & MECHANISMS, Vol: 6, Pages: 643-651, ISSN: 1754-8403
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- Citations: 32
Al-Shieban S, Tadrous PJ, Naresh KN, 2013, Estimation of cell density to aid in assessment of percentage cells of a particular lineage or of cells expressing a specific antigen in bone marrow trephine biopsies, JOURNAL OF CLINICAL PATHOLOGY, Vol: 66, Pages: 155-159, ISSN: 0021-9746
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- Citations: 2
Zhang J, Grubor V, Love CL, et al., 2013, Genetic heterogeneity of diffuse large B-cell lymphoma, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 1398-1403, ISSN: 0027-8424
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- Citations: 423
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